N-((S)-1-(((2S,3S)-3-(2-hydroxyphenyl)-2,3-dimethoxypropyl)(isobutyl)amino)-4-methyl-1-oxopentan-2-yl)benzamide

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Chemical Name:N-((S)-1-(((2S,3S)-3-(2-hydroxyphenyl)-2,3-dimethoxypropyl)(isobutyl)amino)-4-methyl-1-oxopentan-2-yl)benzamide
CAS No.:1421050-60-3
Molecular Formula:C₂₈H₄₀N₂O₅
Molecular Weight:484.636
Hs Code.:

Synonyms:N-((S)-1-(((2S,3S)-3-(2-hydroxyphenyl)-2,3-dimethoxypropyl)(isobutyl)amino)-4-methyl-1-oxopentan-2-yl)benzamide

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Chemical Property of N-((S)-1-(((2S,3S)-3-(2-hydroxyphenyl)-2,3-dimethoxypropyl)(isobutyl)amino)-4-methyl-1-oxopentan-2-yl)benzamide

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Technology Process of N-((S)-1-(((2S,3S)-3-(2-hydroxyphenyl)-2,3-dimethoxypropyl)(isobutyl)amino)-4-methyl-1-oxopentan-2-yl)benzamide

There total 7 articles about N-((S)-1-(((2S,3S)-3-(2-hydroxyphenyl)-2,3-dimethoxypropyl)(isobutyl)amino)-4-methyl-1-oxopentan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₉NO₃

: 1421050-60-3
N-((S)-1-(((2S,3S)-3-(2-hydroxyphenyl)-2,3-dimethoxypropyl)(isobutyl)amino)-4-methyl-1-oxopentan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium cyanoborohydride; acetic acid / ethanol / 1 h / 0 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 0 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.08 h / 20 °C

4: dichloromethane / 0.17 h / 0 °C

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h

With palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol3032126

Reference yield:

: 1421050-51-2
C₂₈H₄₂N₂O₄

: 1421050-60-3
N-((S)-1-(((2S,3S)-3-(2-hydroxyphenyl)-2,3-dimethoxypropyl)(isobutyl)amino)-4-methyl-1-oxopentan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0.17 h / 0 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h

With palladium 10% on activated carbon; hydrogen; In dichloromethane; ethyl acetate;
DOI:10.1021/ol3032126