3-(4-chlorophenyl)-N-(4-ethoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide

Base Information

• Chemical Name: 3-(4-chlorophenyl)-N-(4-ethoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide
• CAS No.: 1380571-34-5
• Molecular Formula: C₂₄H₂₀ClN₃O₂
• Molecular Weight: 417.895
• Mol file: 1380571-34-5.mol

Synonyms:3-(4-chlorophenyl)-N-(4-ethoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide

Chemical Property of 3-(4-chlorophenyl)-N-(4-ethoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-N-(4-ethoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide

There total 5 articles about 3-(4-chlorophenyl)-N-(4-ethoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-Ethoxyaniline (156-43-4) + 1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid (372107-14-7) → 3-(4-chlorophenyl)-N-(4-ethoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide (1380571-34-5)

Guidance literature:

With dmap; potassium carbonate; In dichloromethane; at 40 - 50 ℃; for 12h;

DOI:10.1016/j.bmcl.2012.04.066

Reference yield:

phenylhydrazine hydrochloride (59-88-1) → 3-(4-chlorophenyl)-N-(4-ethoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide (1380571-34-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium acetate / ethanol / 3 h / 50 - 60 °C

2: trichlorophosphate / 6 h / 50 - 60 °C / Cooling

3: sodium chlorite; aminosulfonic acid / acetone / 5 h / 40 - 50 °C

4: dmap; potassium carbonate / dichloromethane / 12 h / 40 - 50 °C

With dmap; sodium chlorite; aminosulfonic acid; sodium acetate; potassium carbonate; trichlorophosphate; In ethanol; dichloromethane; acetone;

DOI:10.1016/j.bmcl.2012.04.066

Reference yield:

1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde (36663-00-0) → 3-(4-chlorophenyl)-N-(4-ethoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide (1380571-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium chlorite; aminosulfonic acid / acetone / 5 h / 40 - 50 °C

2: dmap; potassium carbonate / dichloromethane / 12 h / 40 - 50 °C

With dmap; sodium chlorite; aminosulfonic acid; potassium carbonate; In dichloromethane; acetone;

DOI:10.1016/j.bmcl.2012.04.066

upstream raw materials:

phenylhydrazine hydrochloride

para-chloroacetophenone

4-Ethoxyaniline

1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid