2-butyl-5-nitro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

Base Information

• Chemical Name: 2-butyl-5-nitro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole
• CAS No.: 1421869-04-6
• Molecular Formula: C₂₅H₂₃N₇O₂
• Molecular Weight: 453.503
• Mol file: 1421869-04-6.mol

Synonyms:2-butyl-5-nitro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

Chemical Property of 2-butyl-5-nitro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-butyl-5-nitro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

There total 4 articles about 2-butyl-5-nitro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-butyl-1-[(2'-cyanobiphenyl-4-yl)methyl]-5-nitro-1H-benzimidazole → 2-butyl-5-nitro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole (1421869-04-6)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 84h;

DOI:10.1007/s00044-012-0462-7

Reference yield:

valeric acid (109-52-4) → 2-butyl-5-nitro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole (1421869-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 3.5 h / 170 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 27 °C / Inert atmosphere

2.2: 12 h / 27 °C / Inert atmosphere

3.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 84 h / 120 °C

With sodium azide; potassium carbonate; ammonium chloride; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1007/s00044-012-0462-7

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → 2-butyl-5-nitro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole (1421869-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 3.5 h / 170 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 27 °C / Inert atmosphere

2.2: 12 h / 27 °C / Inert atmosphere

3.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 84 h / 120 °C

With sodium azide; potassium carbonate; ammonium chloride; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1007/s00044-012-0462-7

upstream raw materials:

valeric acid

4-Nitrophenylene-1,2-diamine

2-butyl-5-nitro-1H-benzo[d]imidazole

Downstream raw materials:

5-amino-2-butyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

C₂₇H₂₇N₇

C₂₈H₂₉N₇

C₂₉H₃₁N₇