N-<3-(1-cyclohexylethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Base Information

Chemical Name:N-<3-(1-cyclohexylethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide
CAS No.:200400-66-4
Molecular Formula:C₂₇H₃₁N₃O₄
Molecular Weight:461.561
Hs Code.:

Synonyms:N-<3-(1-cyclohexylethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

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Chemical Property of N-<3-(1-cyclohexylethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

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Technology Process of N-<3-(1-cyclohexylethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

There total 11 articles about N-<3-(1-cyclohexylethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1193-81-3
rac-1-cyclohexylethanol

: 200400-66-4
N-<3-(1-cyclohexylethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 30.3 g / NaOMe / benzene / a) RT, 2 h, b) reflux, 1 h

2: NH₃ liq., H₂ / Raney nickel / ethanol / 2 h / 80 - 85 °C / 67229.2 Torr

3: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 23 h / 0 - 20 °C

With 4-methyl-morpholine; ammonia; hydrogen; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm980173n

Reference yield:

: 200400-18-6
3-(1-cyclohexyl-ethoxy)-propionitrile

: 200400-66-4
N-<3-(1-cyclohexylethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ liq., H₂ / Raney nickel / ethanol / 2 h / 80 - 85 °C / 67229.2 Torr

2: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 23 h / 0 - 20 °C

With 4-methyl-morpholine; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm980173n

Reference yield:

: 200400-64-2
2-<4-(3-pyridylcarbonyl)phenyl>oxazole-4-carboxylic acid

: 200400-17-5
3-propylamine

: 200400-66-4
N-<3-(1-cyclohexylethoxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 23h;
DOI:10.1021/jm980173n