3-(4-ethoxy-3,5-diisopropylphenyl)-β-oxo-propanoic acid methyl ester

Base Information

• Chemical Name: 3-(4-ethoxy-3,5-diisopropylphenyl)-β-oxo-propanoic acid methyl ester
• CAS No.: 1023740-49-9
• Molecular Formula: C₁₈H₂₆O₄
• Molecular Weight: 306.402
• Mol file: 1023740-49-9.mol

Synonyms:3-(4-ethoxy-3,5-diisopropylphenyl)-β-oxo-propanoic acid methyl ester

Chemical Property of 3-(4-ethoxy-3,5-diisopropylphenyl)-β-oxo-propanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(4-ethoxy-3,5-diisopropylphenyl)-β-oxo-propanoic acid methyl ester

There total 2 articles about 3-(4-ethoxy-3,5-diisopropylphenyl)-β-oxo-propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-(4-ethoxy-3,5-diisopropylphenyl)ethanone (1023740-57-9) + carbonic acid dimethyl ester (616-38-6) → 3-(4-ethoxy-3,5-diisopropylphenyl)-β-oxo-propanoic acid methyl ester (1023740-49-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; for 2h; Reflux;

DOI:10.1071/CH09517

Reference yield:

3',5'-diisopropyl-4'-hydroxyacetophenone (720-19-4) → 3-(4-ethoxy-3,5-diisopropylphenyl)-β-oxo-propanoic acid methyl ester (1023740-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone

2: sodium hydride / tetrahydrofuran; mineral oil / 2 h / Reflux

With sodium hydride; potassium carbonate; In tetrahydrofuran; acetone; mineral oil;

DOI:10.1071/CH09517

Reference yield: 37.0%

3-(4-ethoxy-3,5-diisopropylphenyl)-β-oxo-propanoic acid methyl ester (1023740-49-9) → 5-(4-ethoxy-3,5-diisopropylphenyl)-3H-1,2-dithiole-3-thione (1023740-34-2)

Guidance literature:

With sulfur; tetraphosphorus decasulfide; In 5,5-dimethyl-1,3-cyclohexadiene; for 1.5h; Reflux;

DOI:10.1071/CH09517

upstream raw materials:

1-(4-ethoxy-3,5-diisopropylphenyl)ethanone

carbonic acid dimethyl ester

3',5'-diisopropyl-4'-hydroxyacetophenone

Downstream raw materials:

5-(4-ethoxy-3,5-diisopropylphenyl)-3H-1,2-dithiole-3-thione