di-tert-butyl (4S)-4-{3-[(biphenyl-4-ylsulfonyl)oxy]propyl}-N-trityl-L-glutamate

Base Information

Chemical Name:di-tert-butyl (4S)-4-{3-[(biphenyl-4-ylsulfonyl)oxy]propyl}-N-trityl-L-glutamate
CAS No.:1407533-11-2
Molecular Formula:C₄₇H₅₃NO₇S
Molecular Weight:776.006
Hs Code.:

Synonyms:di-tert-butyl (4S)-4-{3-[(biphenyl-4-ylsulfonyl)oxy]propyl}-N-trityl-L-glutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of di-tert-butyl (4S)-4-{3-[(biphenyl-4-ylsulfonyl)oxy]propyl}-N-trityl-L-glutamate

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Technology Process of di-tert-butyl (4S)-4-{3-[(biphenyl-4-ylsulfonyl)oxy]propyl}-N-trityl-L-glutamate

There total 7 articles about di-tert-butyl (4S)-4-{3-[(biphenyl-4-ylsulfonyl)oxy]propyl}-N-trityl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1407533-08-7
di-tert-butyl (4S)-4-(3-hydroxypropyl)-N-trityl-L-glutamate

: 1623-93-4
4-diphenylsulfonyl chloride

: 1407533-11-2
di-tert-butyl (4S)-4-{3-[(biphenyl-4-ylsulfonyl)oxy]propyl}-N-trityl-L-glutamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 5h;

Reference yield: 84.0%

: 1407745-68-9
di-tert-butyl 4-(3-hydroxypropyl)-N-trityl-glutamate

: 1623-93-4
4-diphenylsulfonyl chloride

: 1407533-11-2
di-tert-butyl (4S)-4-{3-[(biphenyl-4-ylsulfonyl)oxy]propyl}-N-trityl-L-glutamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 5h;

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 1407533-11-2
di-tert-butyl (4S)-4-{3-[(biphenyl-4-ylsulfonyl)oxy]propyl}-N-trityl-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C

2.2: 2 h / -78 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

6.1: triethylamine / dichloromethane / 5 h / 0 °C

With tetrabutyl ammonium fluoride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;