N-(tert-butoxy)carbonyl-2-[2,5-dimethoxy-4-(naphthalen-2-yl)phenyl]ethylamine

Base Information

• Chemical Name: N-(tert-butoxy)carbonyl-2-[2,5-dimethoxy-4-(naphthalen-2-yl)phenyl]ethylamine
• CAS No.: 1216821-67-8
• Molecular Formula: C₂₅H₂₉NO₄
• Molecular Weight: 407.51
• Mol file: 1216821-67-8.mol

Synonyms:N-(tert-butoxy)carbonyl-2-[2,5-dimethoxy-4-(naphthalen-2-yl)phenyl]ethylamine

Chemical Property of N-(tert-butoxy)carbonyl-2-[2,5-dimethoxy-4-(naphthalen-2-yl)phenyl]ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butoxy)carbonyl-2-[2,5-dimethoxy-4-(naphthalen-2-yl)phenyl]ethylamine

There total 1 articles about N-(tert-butoxy)carbonyl-2-[2,5-dimethoxy-4-(naphthalen-2-yl)phenyl]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

tert-butyl N-[2-(2,5-dimethoxy-4-iodophenyl)ethyl]carbamate (1216821-16-7) + naphthalene-2-boronic acid (32316-92-0) → N-(tert-butoxy)carbonyl-2-[2,5-dimethoxy-4-(naphthalen-2-yl)phenyl]ethylamine (1216821-67-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 75 ℃; Inert atmosphere;

DOI:10.1002/cbdv.200800235

Reference yield: 82.0%

N-(tert-butoxy)carbonyl-2-[2,5-dimethoxy-4-(naphthalen-2-yl)phenyl]ethylamine (1216821-67-8) → 2-[2,5-dimethoxy-4-(naphthalen-2-yl)phenyl]ethylamine hydrochloride (1216821-45-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 20h; Inert atmosphere;

DOI:10.1002/cbdv.200800235

upstream raw materials:

tert-butyl N-[2-(2,5-dimethoxy-4-iodophenyl)ethyl]carbamate

naphthalene-2-boronic acid

Downstream raw materials:

2-[2,5-dimethoxy-4-(naphthalen-2-yl)phenyl]ethylamine hydrochloride