14-(3-hydroxy-4-methoxyphenyl)-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4′,3':4,5]pyrrolo[2,1-a]-isoquinolin-6-one

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Chemical Name:14-(3-hydroxy-4-methoxyphenyl)-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4′,3':4,5]pyrrolo[2,1-a]-isoquinolin-6-one
CAS No.:1454845-06-7
Molecular Formula:C₃₄H₃₃NO₈
Molecular Weight:583.638
Hs Code.:

Synonyms:14-(3-hydroxy-4-methoxyphenyl)-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4′,3':4,5]pyrrolo[2,1-a]-isoquinolin-6-one

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Chemical Property of 14-(3-hydroxy-4-methoxyphenyl)-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4′,3':4,5]pyrrolo[2,1-a]-isoquinolin-6-one

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Technology Process of 14-(3-hydroxy-4-methoxyphenyl)-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4′,3':4,5]pyrrolo[2,1-a]-isoquinolin-6-one

There total 4 articles about 14-(3-hydroxy-4-methoxyphenyl)-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4′,3':4,5]pyrrolo[2,1-a]-isoquinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1454845-05-6
3,11-diisopropoxy-2,12-dimethoxy-14-[4-methoxy-3-(methoxymethoxy)phenyl]-6H-[1]benzopyrano[4′,3′:4,5]-pyrrolo[2,1-a]isoquinolin-6-one

: 1454845-06-7
14-(3-hydroxy-4-methoxyphenyl)-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4′,3':4,5]pyrrolo[2,1-a]-isoquinolin-6-one

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; at 30 ℃; for 14h;
DOI:10.1021/jm400719y

Reference yield:

: 660397-47-7
8,9-dihydro-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

: 1454845-06-7
14-(3-hydroxy-4-methoxyphenyl)-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4′,3':4,5]pyrrolo[2,1-a]-isoquinolin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h / 0 °C

2: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver(l) oxide / 1,2-dimethoxyethane / 24 h / 85 °C / Inert atmosphere

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 24 h / Inert atmosphere; Reflux

4: hydrogenchloride / dichloromethane; methanol / 14 h / 30 °C

With hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm400719y

Reference yield:

: 660397-48-8
14-bromo-3,11-diisopropoxy-2,12-dimethoxy-8,9-dihydro-6H-[1]benzopyrano[4’,3’:4,5]pyrrolo[2,1-a]isoquinolin-6-one

: 1454845-06-7
14-(3-hydroxy-4-methoxyphenyl)-3,11-diisopropoxy-2,12-dimethoxy-6H-[1]benzopyrano[4′,3':4,5]pyrrolo[2,1-a]-isoquinolin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver(l) oxide / 1,2-dimethoxyethane / 24 h / 85 °C / Inert atmosphere

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 24 h / Inert atmosphere; Reflux

3: hydrogenchloride / dichloromethane; methanol / 14 h / 30 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In methanol; 1,2-dimethoxyethane; dichloromethane; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm400719y