(RS)-5-trifluoromethyl-pyridine-2-carboxylic acid (4-morpholin-2-yl-phenyl)-amide hydrochloride

Base Information

Chemical Name:(RS)-5-trifluoromethyl-pyridine-2-carboxylic acid (4-morpholin-2-yl-phenyl)-amide hydrochloride
CAS No.:1312561-47-9
Molecular Formula:C₁₇H₁₆F₃N₃O₂*ClH
Molecular Weight:387.789
Hs Code.:

Synonyms:(RS)-5-trifluoromethyl-pyridine-2-carboxylic acid (4-morpholin-2-yl-phenyl)-amide hydrochloride

Suppliers and Price of (RS)-5-trifluoromethyl-pyridine-2-carboxylic acid (4-morpholin-2-yl-phenyl)-amide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of (RS)-5-trifluoromethyl-pyridine-2-carboxylic acid (4-morpholin-2-yl-phenyl)-amide hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (RS)-5-trifluoromethyl-pyridine-2-carboxylic acid (4-morpholin-2-yl-phenyl)-amide hydrochloride

There total 3 articles about (RS)-5-trifluoromethyl-pyridine-2-carboxylic acid (4-morpholin-2-yl-phenyl)-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1312565-84-6
(RS)-2-{4-[(5-trifluoromethyl-pyridine-2-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester

: 1312561-47-9
(RS)-5-trifluoromethyl-pyridine-2-carboxylic acid (4-morpholin-2-yl-phenyl)-amide hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 60 ℃;

Reference yield:

: 1131220-82-0
tert-butyl 2-(4-bromophenyl)morpholine-4-carboxylate

: 1312561-47-9
(RS)-5-trifluoromethyl-pyridine-2-carboxylic acid (4-morpholin-2-yl-phenyl)-amide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 2 h / 180 °C / Inert atmosphere; Microwave irradiation

2: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 60 °C

With hydrogenchloride; copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 83555-73-1
(RS)-2-(4-bromophenyl)morpholine

: 1312561-47-9
(RS)-5-trifluoromethyl-pyridine-2-carboxylic acid (4-morpholin-2-yl-phenyl)-amide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C

2: caesium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 2 h / 180 °C / Inert atmosphere; Microwave irradiation

3: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 60 °C

With hydrogenchloride; copper(l) iodide; caesium carbonate; N-ethyl-N,N-diisopropylamine; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane;