dimethyl (2S,4S)-2-(benzyloxy)-4-(2,5-dioxopyrrolidin-1-yl)-2-(m-tolyl)cyclopentane-1,1-dicarboxylate

Base Information

Chemical Name:dimethyl (2S,4S)-2-(benzyloxy)-4-(2,5-dioxopyrrolidin-1-yl)-2-(m-tolyl)cyclopentane-1,1-dicarboxylate
CAS No.:1603818-48-9
Molecular Formula:C₂₇H₂₉NO₇
Molecular Weight:479.53
Hs Code.:

Synonyms:dimethyl (2S,4S)-2-(benzyloxy)-4-(2,5-dioxopyrrolidin-1-yl)-2-(m-tolyl)cyclopentane-1,1-dicarboxylate

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Chemical Property of dimethyl (2S,4S)-2-(benzyloxy)-4-(2,5-dioxopyrrolidin-1-yl)-2-(m-tolyl)cyclopentane-1,1-dicarboxylate

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Technology Process of dimethyl (2S,4S)-2-(benzyloxy)-4-(2,5-dioxopyrrolidin-1-yl)-2-(m-tolyl)cyclopentane-1,1-dicarboxylate

There total 6 articles about dimethyl (2S,4S)-2-(benzyloxy)-4-(2,5-dioxopyrrolidin-1-yl)-2-(m-tolyl)cyclopentane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1603818-35-4
dimethyl 2-(2,5-dioxopyrrolidin-1-yl)cyclopropane-1,1-dicarboxylate

: 1603818-38-7
1-(1-(benzyloxy)vinyl)-3-methylbenzene

: 1603818-48-9
dimethyl (2S,4S)-2-(benzyloxy)-4-(2,5-dioxopyrrolidin-1-yl)-2-(m-tolyl)cyclopentane-1,1-dicarboxylate

Guidance literature:: With C₁₇H₃₀N₂O₂*Cu⁽²⁺⁾*2ClO₄^(1-); In dichloromethane; at 20 ℃; Inert atmosphere; Molecular sieve;
DOI:10.1021/ja5024578

Reference yield:

: 1711-06-4
3-Methylbenzoyl chloride

: 1603818-48-9
dimethyl (2S,4S)-2-(benzyloxy)-4-(2,5-dioxopyrrolidin-1-yl)-2-(m-tolyl)cyclopentane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / diethyl ether / 12 h / Inert atmosphere; Reflux

2: bis(cyclopentadienyl)titanium dichloride / toluene / 16 h / 80 °C / Inert atmosphere

3: C₁₇H₃₀N₂O₂*Cu⁽²⁺⁾*2ClO₄^(1-) / dichloromethane / 20 °C / Inert atmosphere; Molecular sieve

With dmap; bis(cyclopentadienyl)titanium dichloride; C₁₇H₃₀N₂O₂*Cu⁽²⁺⁾*2ClO₄^(1-); triethylamine; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja5024578

Reference yield:

: 6773-29-1
dimethyl diazomalonate

: 1603818-48-9
dimethyl (2S,4S)-2-(benzyloxy)-4-(2,5-dioxopyrrolidin-1-yl)-2-(m-tolyl)cyclopentane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / dichloromethane / 0 - 20 °C / Inert atmosphere

2: C₁₇H₃₀N₂O₂*Cu⁽²⁺⁾*2ClO₄^(1-) / dichloromethane / 20 °C / Inert atmosphere; Molecular sieve

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; C₁₇H₃₀N₂O₂*Cu⁽²⁺⁾*2ClO₄^(1-); In dichloromethane;
DOI:10.1021/ja5024578