(rac)-7-(4-Cyanophenyl)-5-methyl-2-(1-methylethyl)-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Chemical Name:(rac)-7-(4-Cyanophenyl)-5-methyl-2-(1-methylethyl)-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile
CAS No.:1234620-11-1
Molecular Formula:C₂₄H₁₉F₃N₆
Molecular Weight:448.45
Hs Code.:

Synonyms:(rac)-7-(4-Cyanophenyl)-5-methyl-2-(1-methylethyl)-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Chemical Property of (rac)-7-(4-Cyanophenyl)-5-methyl-2-(1-methylethyl)-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Technology Process of (rac)-7-(4-Cyanophenyl)-5-methyl-2-(1-methylethyl)-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

There total 3 articles about (rac)-7-(4-Cyanophenyl)-5-methyl-2-(1-methylethyl)-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1234620-80-4
7-(4-Cyanophenyl)-5-methyl-2-(propan-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1234620-11-1
(rac)-7-(4-Cyanophenyl)-5-methyl-2-(1-methylethyl)-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: With pyridine; copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 84h; Inert atmosphere; Molecular sieve;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1234620-11-1
(rac)-7-(4-Cyanophenyl)-5-methyl-2-(1-methylethyl)-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine; acetic acid / dichloromethane / 18 h / Reflux

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 55 °C / Inert atmosphere

3: triethylamine; pyridine; copper diacetate / dichloromethane / 84 h / 20 °C / Inert atmosphere; Molecular sieve

With piperidine; pyridine; copper diacetate; sodium hydrogencarbonate; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1234620-56-4
4-(2-cyano-3-oxobut-1-en-1-yl)benzonitrile

: 1234620-11-1
(rac)-7-(4-Cyanophenyl)-5-methyl-2-(1-methylethyl)-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 55 °C / Inert atmosphere

2: triethylamine; pyridine; copper diacetate / dichloromethane / 84 h / 20 °C / Inert atmosphere; Molecular sieve

With pyridine; copper diacetate; sodium hydrogencarbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;