N-hydroxy-3-(trifluoromethyl)benzamide

Base Information

• Chemical Name: N-hydroxy-3-(trifluoromethyl)benzamide
• CAS No.: 40069-06-5
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.136
• Mol file: 40069-06-5.mol

Synonyms:N-hydroxy-3-(trifluoromethyl)benzamide

Chemical Property of N-hydroxy-3-(trifluoromethyl)benzamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-hydroxy-3-(trifluoromethyl)benzamide ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

Useful:

Technology Process of N-hydroxy-3-(trifluoromethyl)benzamide

There total 3 articles about N-hydroxy-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(Trifluoromethyl)benzoyl chloride (2251-65-2) → N-hydroxy-3-(trifluoromethyl)benzamide (40069-06-5)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In water; at 0 ℃; Yield given;

Reference yield:

3-trifluoromethylbenzoic acid methyl ester (2557-13-3) → N-hydroxy-3-(trifluoromethyl)benzamide (40069-06-5)

Guidance literature:

With sodium hydroxide; hydroxylamine; In methanol;

DOI:10.1021/jm00281a032

Reference yield:

3-(trifluoromethyl)benzoic acid (454-92-2) → N-hydroxy-3-(trifluoromethyl)benzamide (40069-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium hydroxide / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; hydroxylamine hydrochloride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jacs.0c02813

upstream raw materials:

3-trifluoromethylbenzoic acid methyl ester

3-(Trifluoromethyl)benzoyl chloride

3-(trifluoromethyl)benzoic acid

Downstream raw materials:

N-(4-Trichloromethyl-benzoyloxy)-3-trifluoromethyl-benzamide

3-Trifluoromethyl-N-(3-trifluoromethyl-benzoyloxy)-benzamide

3-Trifluoromethyl-N-(4-trifluoromethyl-benzoyloxy)-benzamide

7-(trifluoromethyl)-3,4-diphenylisoquinolin-1(2H)-one