4-hydroxy-1-(2',5'-dichloro-4'-sulphophenyl)-3-[N-(2'-oxobenzimidazol-5'-yl)carboxamide]pyrazole

Base Information

• Chemical Name: 4-hydroxy-1-(2',5'-dichloro-4'-sulphophenyl)-3-[N-(2'-oxobenzimidazol-5'-yl)carboxamide]pyrazole
• CAS No.: 776325-76-9
• Molecular Formula: C₁₇H₁₁Cl₂N₅O₆S
• Molecular Weight: 484.276
• Mol file: 776325-76-9.mol

Synonyms:4-hydroxy-1-(2',5'-dichloro-4'-sulphophenyl)-3-[N-(2'-oxobenzimidazol-5'-yl)carboxamide]pyrazole

Chemical Property of 4-hydroxy-1-(2',5'-dichloro-4'-sulphophenyl)-3-[N-(2'-oxobenzimidazol-5'-yl)carboxamide]pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-1-(2',5'-dichloro-4'-sulphophenyl)-3-[N-(2'-oxobenzimidazol-5'-yl)carboxamide]pyrazole

There total 4 articles about 4-hydroxy-1-(2',5'-dichloro-4'-sulphophenyl)-3-[N-(2'-oxobenzimidazol-5'-yl)carboxamide]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-{N'-[3-bromo-2-oxo-1-(2-oxo-2,3-dihydro-1H-benzoimidazol-5-ylcarbamoyl)-propylidene]-hydrazino}-2,5-dichloro-benzenesulfonic acid → 4-hydroxy-1-(2',5'-dichloro-4'-sulphophenyl)-3-[N-(2'-oxobenzimidazol-5'-yl)carboxamide]pyrazole (776325-76-9)

Guidance literature:

With sodium acetate; In propan-1-ol; for 3h; Heating;

DOI:10.1080/10426500490459858

Reference yield:

1-amino-2,5-dichlorobenzene-4-sulphonic acid (88-50-6) → 4-hydroxy-1-(2',5'-dichloro-4'-sulphophenyl)-3-[N-(2'-oxobenzimidazol-5'-yl)carboxamide]pyrazole (776325-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate; sodium nitrite; aq. hydrochloric acid / 0.42 h / cooling

1.2: 70 percent / aq. sodium hydroxide / 0 - 3 °C

2.1: 74 percent / aq. sodium acetate / propan-1-ol / 3 h / Heating

With hydrogenchloride; sodium acetate; sodium carbonate; sodium nitrite; In propan-1-ol;

DOI:10.1080/10426500490459858

Reference yield:

5-Acetoacetyl-amino-benzimidazol-2-one (26576-46-5) → 4-hydroxy-1-(2',5'-dichloro-4'-sulphophenyl)-3-[N-(2'-oxobenzimidazol-5'-yl)carboxamide]pyrazole (776325-76-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 46 percent / bromine / CHCl₃

2.1: sodium carbonate; sodium nitrite; aq. hydrochloric acid / 0.42 h / cooling

2.2: 70 percent / aq. sodium hydroxide / 0 - 3 °C

3.1: 74 percent / aq. sodium acetate / propan-1-ol / 3 h / Heating

With hydrogenchloride; bromine; sodium acetate; sodium carbonate; sodium nitrite; In propan-1-ol; chloroform;

DOI:10.1080/10426500490459858

upstream raw materials:

1-amino-2,5-dichlorobenzene-4-sulphonic acid

5-Acetoacetyl-amino-benzimidazol-2-one

4-bromo-3-oxo-N-(2'-oxobenzimidazol-5'-yl)butyramide