methyl 3-[3-(2-hydroxy-5-methylphenyl)-3-oxopropanoyl]-5-methoxybenzoate

Base Information

Chemical Name:methyl 3-[3-(2-hydroxy-5-methylphenyl)-3-oxopropanoyl]-5-methoxybenzoate
CAS No.:742101-59-3
Molecular Formula:C₁₉H₁₈O₆
Molecular Weight:342.348
Hs Code.:

Synonyms:methyl 3-[3-(2-hydroxy-5-methylphenyl)-3-oxopropanoyl]-5-methoxybenzoate

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Chemical Property of methyl 3-[3-(2-hydroxy-5-methylphenyl)-3-oxopropanoyl]-5-methoxybenzoate

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Technology Process of methyl 3-[3-(2-hydroxy-5-methylphenyl)-3-oxopropanoyl]-5-methoxybenzoate

There total 8 articles about methyl 3-[3-(2-hydroxy-5-methylphenyl)-3-oxopropanoyl]-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 742101-54-8
2-acetyl-4-methylphenyl methyl 5-methoxyisophthalate

: 742101-59-3
methyl 3-[3-(2-hydroxy-5-methylphenyl)-3-oxopropanoyl]-5-methoxybenzoate

Guidance literature:: With pyridine; potassium hydroxide; at 50 ℃; for 1.5h;
DOI:10.1021/jm020839k

Reference yield:

: 618-83-7
5-Hydroxyisophthalic acid

: 742101-59-3
methyl 3-[3-(2-hydroxy-5-methylphenyl)-3-oxopropanoyl]-5-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / K₂CO₃ / dimethylformamide / 14 h / 40 °C

2: 33 percent / LiOH / tetrahydrofuran; H₂O / 2.5 h / 20 °C

3: SOCl₂; DMF / Heating

4: 73 percent / pyridine / 0.5 h / 50 °C

5: 67 percent / pyridine; KOH / 1.5 h / 50 °C

With pyridine; potassium hydroxide; lithium hydroxide; thionyl chloride; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 4: Schotten-Baumann reaction / 5: Baker Venkataraman rearrangement;
DOI:10.1021/jm020839k

Reference yield:

: 20319-44-2
dimethyl 5-methoxyisophthalate

: 742101-59-3
methyl 3-[3-(2-hydroxy-5-methylphenyl)-3-oxopropanoyl]-5-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 33 percent / LiOH / tetrahydrofuran; H₂O / 2.5 h / 20 °C

2: SOCl₂; DMF / Heating

3: 73 percent / pyridine / 0.5 h / 50 °C

4: 67 percent / pyridine; KOH / 1.5 h / 50 °C

With pyridine; potassium hydroxide; lithium hydroxide; thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; water; 3: Schotten-Baumann reaction / 4: Baker Venkataraman rearrangement;
DOI:10.1021/jm020839k