tert-butyl 4--6-quinazolinyl>methyl>amino>-2-fluorobenzoate

Base Information

Chemical Name:tert-butyl 4--6-quinazolinyl>methyl>amino>-2-fluorobenzoate
CAS No.:145789-15-7
Molecular Formula:C₂₇H₃₂FN₃O₅
Molecular Weight:497.567
Hs Code.:

tert-butyl 4-<N-<<3,4-dihydro-2-methyl-4-oxo-3-<(pivaloyloxy)methyl>-6-quinazolinyl>methyl>amino>-2-fluorobenzoate

Synonyms:tert-butyl 4--6-quinazolinyl>methyl>amino>-2-fluorobenzoate

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Chemical Property of tert-butyl 4--6-quinazolinyl>methyl>amino>-2-fluorobenzoate

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Technology Process of tert-butyl 4--6-quinazolinyl>methyl>amino>-2-fluorobenzoate

There total 2 articles about tert-butyl 4--6-quinazolinyl>methyl>amino>-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 112888-39-8
6-bromomethyl-3,4-dihydro-2-methyl-4-oxo-3-((pivaloyl)oxy)methylquinazoline

: 140373-77-9
tert-butyl 2-fluoro-4-aminobenzoate

: 145789-15-7
tert-butyl 4--6-quinazolinyl>methyl>amino>-2-fluorobenzoate

Guidance literature:: With 2,6-dimethylpyridine; sodium iodide; In N,N-dimethyl acetamide; at 95 ℃; for 10h;
DOI:10.1021/jm950471+

Reference yield:

: 108-48-5
2,6-dimethylpyridine

: 112888-39-8
6-bromomethyl-3,4-dihydro-2-methyl-4-oxo-3-((pivaloyl)oxy)methylquinazoline

: 140373-77-9
tert-butyl 2-fluoro-4-aminobenzoate

: 145789-15-7
tert-butyl 4--6-quinazolinyl>methyl>amino>-2-fluorobenzoate

Guidance literature:: In hexane; ISOPROPYLAMIDE; ethyl acetate;

Reference yield:

: 145789-15-7
tert-butyl 4--6-quinazolinyl>methyl>amino>-2-fluorobenzoate

: 4--6-quinazolinyl>methyl>N-methylamino>-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) aq. AcOH, 2.) NaBH₃(CN) / 1.) RT, 10 min

2: 4.54 g / TFA / 1 h / Ambient temperature

3: aq. NaOH / ethanol / 4 h / Ambient temperature

With sodium hydroxide; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In ethanol;
DOI:10.1021/jm950471+