Technology Process of {3,3-difluoro-1-[4-(trifluoromethyl)phenyl]cyclobutyl}(pyridin-2-yl)-methanol
There total 7 articles about {3,3-difluoro-1-[4-(trifluoromethyl)phenyl]cyclobutyl}(pyridin-2-yl)-methanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methanol; sodium tetrahydroborate;
at 0 - 20 ℃;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / toluene / 2 h / 20 °C / Reflux
2.1: potassium hexamethylsilazane / toluene / 24 h / 60 °C
3.1: trifluoroacetic acid / 24 h / 25 °C
4.1: diethylamino-sulfur trifluoride / dichloromethane / 18 h / 0 - 20 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
5.2: 0.75 h / -78 °C
6.1: methanol; sodium tetrahydroborate / 0.25 h / 0 - 20 °C
With
methanol; sodium tetrahydroborate; n-butyllithium; diethylamino-sulfur trifluoride; potassium hexamethylsilazane; toluene-4-sulfonic acid; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ruthenium(III) trichloride hydrate; sodium periodate / water; dichloromethane; acetonitrile / 0.17 h / 5 - 20 °C
2.1: toluene-4-sulfonic acid / toluene / 2 h / 20 °C / Reflux
3.1: potassium hexamethylsilazane / toluene / 24 h / 60 °C
4.1: trifluoroacetic acid / 24 h / 25 °C
5.1: diethylamino-sulfur trifluoride / dichloromethane / 18 h / 0 - 20 °C
6.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
6.2: 0.75 h / -78 °C
7.1: methanol; sodium tetrahydroborate / 0.25 h / 0 - 20 °C
With
methanol; sodium tetrahydroborate; sodium periodate; n-butyllithium; diethylamino-sulfur trifluoride; ruthenium(III) trichloride hydrate; potassium hexamethylsilazane; toluene-4-sulfonic acid; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane; water; toluene; acetonitrile;
