(R)-(-)-6-benzyloxy-3-[(E)-1,3-diphenyl-2-propen-1-yl]-1H-indole

Base Information

• Chemical Name: (R)-(-)-6-benzyloxy-3-[(E)-1,3-diphenyl-2-propen-1-yl]-1H-indole
• CAS No.: 1431640-81-1
• Molecular Formula: C₃₀H₂₅NO
• Molecular Weight: 415.535
• Mol file: 1431640-81-1.mol

Synonyms:(R)-(-)-6-benzyloxy-3-[(E)-1,3-diphenyl-2-propen-1-yl]-1H-indole

Chemical Property of (R)-(-)-6-benzyloxy-3-[(E)-1,3-diphenyl-2-propen-1-yl]-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (R)-(-)-6-benzyloxy-3-[(E)-1,3-diphenyl-2-propen-1-yl]-1H-indole

There total 2 articles about (R)-(-)-6-benzyloxy-3-[(E)-1,3-diphenyl-2-propen-1-yl]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-benzyloxy-1H-indole (15903-94-3) + 3-acetoxy-1,3-diphenylpropene (73930-97-9) → (R)-(-)-6-benzyloxy-3-[(E)-1,3-diphenyl-2-propen-1-yl]-1H-indole (1431640-81-1)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); potassium acetate; (S)-N-(2-(diphenylphosphaneyl)-6-methylphenyl)-N-(1-phenylethyl)cinnamamide; In acetonitrile; at 40 ℃; for 18h; enantioselective reaction; Inert atmosphere;

DOI:10.1039/d1ob02086b

Reference yield:

6-benzyloxy-1H-indole (15903-94-3) + rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene (87751-69-7) → (S)-(-)-6-benzyloxy-3-[(E)-1,3-diphenyl-2-propen-1-yl]-1H-indole + (R)-(-)-6-benzyloxy-3-[(E)-1,3-diphenyl-2-propen-1-yl]-1H-indole (1431640-81-1)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); (aS)-(+)-N-(2'-diphenylphosphino-6'-trifluoromethylphenyl)indole; potassium carbonate; In toluene; at 20 ℃; for 18h; Overall yield = 69 %; Overall yield = 57.4 mg; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2013.03.008

upstream raw materials:

6-benzyloxy-1H-indole

rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene

3-acetoxy-1,3-diphenylpropene