isoxazoline

Base Information

• Chemical Name: isoxazoline
• CAS No.: 1373498-16-8
• Molecular Formula: C₁₉H₃₅NO₂Si
• Molecular Weight: 337.578
• Mol file: 1373498-16-8.mol

Synonyms:isoxazoline

Chemical Property of isoxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isoxazoline

There total 5 articles about isoxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

acetohydroximoyl chloride (683-58-9) + C17H32OSi (1373498-19-1) → isoxazoline (1373498-16-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1055/s-0031-1290353

Reference yield:

C17H32OSi (1373498-21-5) → isoxazoline (1373498-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst second generation; ethene / toluene / 3 h / 80 °C

2: triethylamine / dichloromethane / 10 h / 20 °C

With Hoveyda-Grubbs catalyst second generation; ethene; triethylamine; In dichloromethane; toluene;

DOI:10.1055/s-0031-1290353

Reference yield:

3,3-dimethylpent-4-ynal (35849-64-0) → isoxazoline (1373498-16-8)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / 0 °C

2: 2,6-dimethylpyridine / 20 °C

3: Hoveyda-Grubbs catalyst second generation; ethene / toluene / 3 h / 80 °C

4: triethylamine / dichloromethane / 10 h / 20 °C

With 2,6-dimethylpyridine; Hoveyda-Grubbs catalyst second generation; ethene; triethylamine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1055/s-0031-1290353

upstream raw materials:

C₁₁H₁₈O

acetohydroximoyl chloride

C₁₇H₃₂OSi

C₁₇H₃₂OSi

Downstream raw materials:

C₁₉H₃₆O₃Si

C₁₉H₃₄O₂Si

(+/-)-3-hydroxy-β-ionone