2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine

Base Information

Chemical Name:2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine
CAS No.:122757-53-3
Molecular Formula:C₉H₁₀FN₃O₃
Molecular Weight:227.195
Hs Code.:
Mol file:122757-53-3.mol

Synonyms:Cytidine,2',3'-didehydro-2',3'-dideoxy-2'-fluoro- (9CI); 2',3'-Dideoxy-2',3'-didehydro-2'-fluorocytidine

Suppliers and Price of 2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine

Chemical Property:

Boiling Point:434.4°Cat760mmHg
Flash Point:216.5°C
PSA：90.37000
Density:1.66g/cm³
LogP:0.14980

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine

There total 24 articles about 2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: N-[1-((2R,5S)-3-Fluoro-5-hydroxymethyl-2,5-dihydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide

: 122757-53-3
1-(2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl)cytosine

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 8h;
DOI:10.1021/jm010418n

Reference yield: 70.4%

: 124424-36-8
1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine

: 122757-53-3
1-(2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl)cytosine

Guidance literature:: With acetic acid; for 5h; Ambient temperature;
DOI:10.1021/jm00170a017

Reference yield:

: 69123-98-4
fialuridine

: 122757-53-3
1-(2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl)cytosine

Guidance literature:: Multi-step reaction with 8 steps

1: 90.3 percent / H₂, Et₃N / 10percent Pd/C / methanol; H₂O / 18 h / 2068.6 Torr

2: 89.3 percent / pyridine / 18 h / Ambient temperature

3: 100 percent / pyridine / 16 h / 0 °C

4: 83.5 percent / 1 N aq. NaOH / ethanol / 4 h / Heating

5: 95.2 percent / t-BuOK / dimethylsulfoxide / 1 h / Ambient temperature

6: p-chlorophenyl phosphodichloridate, pyridine / 72 h / Ambient temperature

7: conc. aq. NH₃ / dioxane / 5 h / Ambient temperature

8: 70.4 percent / 80percent aq. AcOH / 5 h / Ambient temperature

With pyridine; ammonium hydroxide; sodium hydroxide; potassium tert-butylate; hydrogen; acetic acid; triethylamine; 4-chlorophenylphosphorodichloridate; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00170a017