(1S,2R)-2-((5-ethylthiophen-2-yl)methyleneamino)-1-phenylpropan-1-ol

Base Information

• Chemical Name: (1S,2R)-2-((5-ethylthiophen-2-yl)methyleneamino)-1-phenylpropan-1-ol
• CAS No.: 1431846-76-2
• Molecular Formula: C₁₆H₁₉NOS
• Molecular Weight: 273.399
• Mol file: 1431846-76-2.mol

Synonyms:(1S,2R)-2-((5-ethylthiophen-2-yl)methyleneamino)-1-phenylpropan-1-ol

Chemical Property of (1S,2R)-2-((5-ethylthiophen-2-yl)methyleneamino)-1-phenylpropan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-2-((5-ethylthiophen-2-yl)methyleneamino)-1-phenylpropan-1-ol

There total 2 articles about (1S,2R)-2-((5-ethylthiophen-2-yl)methyleneamino)-1-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-ethyl-thiophene-2-carbaldehyde (36880-33-8) + (1S,2R)-(+)-norphedrine (37577-28-9,58550-13-3,757124-50-8) → (1S,2R)-2-((5-ethylthiophen-2-yl)methyleneamino)-1-phenylpropan-1-ol (1431846-76-2)

Guidance literature:

In benzene; for 4h; Reflux; Dean-Stark;

DOI:10.1134/S1070428020050255

Reference yield:

2-ethylthiophene (872-55-9) → (1S,2R)-2-((5-ethylthiophen-2-yl)methyleneamino)-1-phenylpropan-1-ol (1431846-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / dichloromethane / 0.5 h / 0 °C

1.2: 0 - 110 °C

2.1: benzene / 4 h / Inert atmosphere; Reflux; Dean-Stark

With trichlorophosphate; In dichloromethane; benzene; 1.1: |Vilsmeier-Haack Formylation / 1.2: |Vilsmeier-Haack Formylation;

DOI:10.1002/aoc.2969

Reference yield: 75.0%

(1S,2R)-2-((5-ethylthiophen-2-yl)methyleneamino)-1-phenylpropan-1-ol (1431846-76-2) → (1S,2R)-2-(5-ethylthiophen-2-yl)methylamino-1-phenylpropanol (1431846-80-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1134/S1070428020050255

upstream raw materials:

5-ethyl-thiophene-2-carbaldehyde

(1S,2R)-(+)-norphedrine

2-ethylthiophene

Downstream raw materials:

(1S,2R)-2-(5-ethylthiophen-2-yl)methylamino-1-phenylpropanol