(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid ethyl ester; hydrochloride

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Chemical Name:(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid ethyl ester; hydrochloride
CAS No.:96846-24-1
Molecular Formula:C₂₀H₂₅N₉O₃*2ClH
Molecular Weight:512.399
Hs Code.:

Synonyms:(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid ethyl ester; hydrochloride

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Chemical Property of (S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid ethyl ester; hydrochloride

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Technology Process of (S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid ethyl ester; hydrochloride

There total 5 articles about (S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 96846-12-7
(S)-3-tert-Butoxycarbonylamino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid ethyl ester

: 96846-24-1
(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid ethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 - 25 ℃; for 16h;
DOI:10.1021/jm00146a008

Reference yield:

: 96845-94-2
ethyl N²-<4-<<(benzyloxy)carbonyl>methylamino>benzoyl>-N³-<(1,1-dimethylethoxy)carbonyl>-2,3-diaminopropanoic acid

: 96846-24-1
(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / (i-Pr)2NEt / dimethylformamide / 120 h / 20 - 25 °C

2: 97 percent / H₂ / 5percent Pd/C / dioxane / 760 Torr / Ambient temperature

3: 79 percent / N,N-dimethyl-acetamide / 144 h

4: 98 percent / HCl (gas) / ethanol; dioxane / 16 h / 20 - 25 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00146a008

Reference yield:

: 96845-90-8
ethyl N²-<4-<<(benzyloxy)carbonyl>methylamino>benzoyl>-N³-<(1,1-dimethylethoxy)carbonyl>-2,3-diaminopropanoate

: 96846-24-1
(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / H₂ / 5percent Pd/C / dioxane / 760 Torr / Ambient temperature

2: 79 percent / N,N-dimethyl-acetamide / 144 h

3: 98 percent / HCl (gas) / ethanol; dioxane / 16 h / 20 - 25 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm00146a008