7-<2-ethyl-4-(3-fluorophenyl)-5-(benzyloxy)phenoxy>-2-methyl-2-(1H-tetrazol-5-yl) heptane

Base Information

Chemical Name:7-<2-ethyl-4-(3-fluorophenyl)-5-(benzyloxy)phenoxy>-2-methyl-2-(1H-tetrazol-5-yl) heptane
CAS No.:152608-87-2
Molecular Formula:C₃₀H₃₅FN₄O₂
Molecular Weight:502.632
Hs Code.:

Synonyms:7-<2-ethyl-4-(3-fluorophenyl)-5-(benzyloxy)phenoxy>-2-methyl-2-(1H-tetrazol-5-yl) heptane

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Chemical Property of 7-<2-ethyl-4-(3-fluorophenyl)-5-(benzyloxy)phenoxy>-2-methyl-2-(1H-tetrazol-5-yl) heptane

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Technology Process of 7-<2-ethyl-4-(3-fluorophenyl)-5-(benzyloxy)phenoxy>-2-methyl-2-(1H-tetrazol-5-yl) heptane

There total 7 articles about 7-<2-ethyl-4-(3-fluorophenyl)-5-(benzyloxy)phenoxy>-2-methyl-2-(1H-tetrazol-5-yl) heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 152608-87-2
7-<2-ethyl-4-(3-fluorophenyl)-5-(benzyloxy)phenoxy>-2-methyl-2-(1H-tetrazol-5-yl) heptane

Guidance literature:

Reference yield: 72.0%

: 152608-85-0
1-(benzyloxy)-4-ethyl-2-(3-fluorophenyl)-5-<(6-methyl-6-cyanoheptyl)oxy>benzene

: 152608-87-2
7-<2-ethyl-4-(3-fluorophenyl)-5-(benzyloxy)phenoxy>-2-methyl-2-(1H-tetrazol-5-yl) heptane

Guidance literature:: With sodium azide; triethylamine hydrochloride; In N,N-dimethyl-formamide; at 125 ℃; for 17h;
DOI:10.1021/jm00022a006

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 152608-87-2
7-<2-ethyl-4-(3-fluorophenyl)-5-(benzyloxy)phenoxy>-2-methyl-2-(1H-tetrazol-5-yl) heptane

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / K₂CO₃, KI / dimethylformamide / 24 h / 90 °C

2: 92 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 98 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 80 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 72 percent / Et₃N*HCl, NaN₃ / dimethylformamide / 17 h / 125 °C

With triethylsilane; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; triethylamine hydrochloride; sodium carbonate; potassium carbonate; trifluoroacetic acid; potassium iodide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00022a006