1-(2-methoxymethoxy-5-nitro)phenyl-4-phenylbutyne

Base Information

Chemical Name:1-(2-methoxymethoxy-5-nitro)phenyl-4-phenylbutyne
CAS No.:474454-62-1
Molecular Formula:C₁₈H₁₇NO₄
Molecular Weight:311.337
Hs Code.:

Synonyms:1-(2-methoxymethoxy-5-nitro)phenyl-4-phenylbutyne

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-methoxymethoxy-5-nitro)phenyl-4-phenylbutyne

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Technology Process of 1-(2-methoxymethoxy-5-nitro)phenyl-4-phenylbutyne

There total 2 articles about 1-(2-methoxymethoxy-5-nitro)phenyl-4-phenylbutyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 16520-62-0
4-Phenyl-1-butyne

: 373380-62-2
2-bromo-1-(methoxymethoxy)-4-nitrobenzene

: 474454-62-1
1-(2-methoxymethoxy-5-nitro)phenyl-4-phenylbutyne

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; diethylamine; copper(l) iodide; triphenylphosphine; at 50 - 60 ℃; for 6h;
DOI:10.1021/jm0202270

Reference yield:

: 5847-59-6
2-bromo-4-nitrophenol

: 474454-62-1
1-(2-methoxymethoxy-5-nitro)phenyl-4-phenylbutyne

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h

1.2: 90 percent / tetrahydrofuran / 24 h / 20 °C

2.1: 100 percent / bis(triphenylphosphine0palladium(II) chloride; diethylamine / triphenylphosphine; CuI / 6 h / 50 - 60 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; diethylamine; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; 2.1: Sonogashira reaction;
DOI:10.1021/jm0202270