C₁₉H₁₇ClF₃N₅O₂

Base Information

• Chemical Name: C₁₉H₁₇ClF₃N₅O₂
• CAS No.: 863910-56-9
• Molecular Formula: C₁₉H₁₇ClF₃N₅O₂
• Molecular Weight: 439.824
• Mol file: 863910-56-9.mol

Synonyms:C₁₉H₁₇ClF₃N₅O₂

Chemical Property of C₁₉H₁₇ClF₃N₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₇ClF₃N₅O₂

There total 10 articles about C₁₉H₁₇ClF₃N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

N-[5-(2-aminoethyl)-1H-benzoimidazol-2-yl]-acetamide (863910-60-5) + 4-chloro-3-(trifluoromethyl)phenyl isocyanate (327-78-6) → C19H17ClF3N5O2 (863910-56-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2011.02.108

Reference yield:

N-<2-(4-nitrophenyl)ethyl>acetamide (6270-07-1) → C19H17ClF3N5O2 (863910-56-9)

Guidance literature:

Multi-step reaction with 10 steps

1.1: ammonia; hydrogen / ethanol / 21 h / 45 °C

2.1: 0.25 h / 20 °C

3.1: nitric acid; acetic anhydride / 20 h / 0 - 20 °C

4.1: hydrogenchloride; water / 18 h / Reflux

5.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 0 - 20 °C

6.1: palladium on activated charcoal; hydrogen / methanol / 20 h / 20 °C

7.1: water / methanol; acetonitrile / 1 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

8.2: 3 h / 100 °C

9.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

10.1: dichloromethane / 3 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; ammonia; water; hydrogen; nitric acid; acetic anhydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;

DOI:10.1016/j.bmcl.2011.02.108

Reference yield:

C16H22N4O3 (1207273-19-5) → C19H17ClF3N5O2 (863910-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2: dichloromethane / 3 h / 20 °C

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2011.02.108

upstream raw materials:

C₁₆H₂₂N₄O₃

C₁₄H₂₀N₄O₂

N-[5-(2-aminoethyl)-1H-benzoimidazol-2-yl]-acetamide

4-chloro-3-(trifluoromethyl)phenyl isocyanate