(3R,5S,6R)-3-Allyl-7-benzyloxy-5-hydroxy-6-methyl-heptanoic acid methyl ester

Base Information

Chemical Name:(3R,5S,6R)-3-Allyl-7-benzyloxy-5-hydroxy-6-methyl-heptanoic acid methyl ester
CAS No.:909257-56-3
Molecular Formula:C₁₉H₂₈O₄
Molecular Weight:320.429
Hs Code.:

Synonyms:(3R,5S,6R)-3-Allyl-7-benzyloxy-5-hydroxy-6-methyl-heptanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5S,6R)-3-Allyl-7-benzyloxy-5-hydroxy-6-methyl-heptanoic acid methyl ester

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Technology Process of (3R,5S,6R)-3-Allyl-7-benzyloxy-5-hydroxy-6-methyl-heptanoic acid methyl ester

There total 6 articles about (3R,5S,6R)-3-Allyl-7-benzyloxy-5-hydroxy-6-methyl-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 909257-68-7
(3R,5S,6R)-3-Allyl-7-benzyloxy-5-hydroxy-6-methyl-heptanoic acid

: 909257-56-3
(3R,5S,6R)-3-Allyl-7-benzyloxy-5-hydroxy-6-methyl-heptanoic acid methyl ester

Guidance literature:: In dichloromethane;
DOI:10.1016/j.tetlet.2006.06.046

Reference yield:

: 909257-66-5
Acrylic acid (S)-1-((R)-2-benzyloxy-1-methyl-ethyl)-but-3-enyl ester

: 909257-56-3
(3R,5S,6R)-3-Allyl-7-benzyloxy-5-hydroxy-6-methyl-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Grubbs' catalyst

2: 85 percent / tetrahydrofuran / -78 - -40 °C

3: 100 percent / LiOH / methanol

4: 90 percent / CH₂Cl₂

With lithium hydroxide; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; 2: Michael reaction;
DOI:10.1016/j.tetlet.2006.06.046

Reference yield:

: 79026-61-2
(R)-3-benzyloxy-2-methylpropanal

: 909257-56-3
(3R,5S,6R)-3-Allyl-7-benzyloxy-5-hydroxy-6-methyl-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / SnCl₄ / CH₂Cl₂ / -90 °C

2: 80 percent / Et₃N / CH₂Cl₂

3: 80 percent / Grubbs' catalyst

4: 85 percent / tetrahydrofuran / -78 - -40 °C

5: 100 percent / LiOH / methanol

6: 90 percent / CH₂Cl₂

With lithium hydroxide; tin(IV) chloride; triethylamine; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; 1: Mitsunobu reaction / 4: Michael reaction;
DOI:10.1016/j.tetlet.2006.06.046