2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid

Base Information

Chemical Name:2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid
CAS No.:875271-94-6
Molecular Formula:C₃₇H₃₈N₂O₅S
Molecular Weight:622.785
Hs Code.:

Synonyms:2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid

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Chemical Property of 2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid

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Technology Process of 2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid

There total 10 articles about 2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 875271-93-5
2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid methyl ester

: 875271-94-6
2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid

Guidance literature:: With sodium hydroxide; In methanol; for 4h; Heating;
DOI:10.1016/j.bmc.2005.08.018

Reference yield:

: 875271-79-7
(2-phenylthiophen-3-yl)acetic acid methyl ester

: 875271-94-6
2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / AlCl₃ / CH₂Cl₂ / 20 °C

2: 96 percent / stannous chloride dihydrate / ethyl acetate / 0.5 h / Heating

3: 98 percent / Et₂NH; CuI / Pd(PPh₃)4 / 4 h / 20 °C

4: 61 percent / PdCl₂(PhCN)2 / dimethylformamide / 0.5 h / 80 °C

5: 77 percent / CsF on Celite / acetonitrile / 24 h / Heating

6: 100 percent / NaOH / methanol / 4 h / Heating

With sodium hydroxide; copper(l) iodide; aluminium trichloride; diethylamine; cesium fluoride; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.08.018

Reference yield:

: 875271-86-6
(2-phenylthiophen-3-yl)acetic acid ethyl ester

: 875271-94-6
2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: KOH / methanol / 3 h / Heating

2: 3.3 g / HCl / 5 h / Heating

3: 74 percent / AlCl₃ / CH₂Cl₂ / 20 °C

4: 96 percent / stannous chloride dihydrate / ethyl acetate / 0.5 h / Heating

5: 98 percent / Et₂NH; CuI / Pd(PPh₃)4 / 4 h / 20 °C

6: 61 percent / PdCl₂(PhCN)2 / dimethylformamide / 0.5 h / 80 °C

7: 77 percent / CsF on Celite / acetonitrile / 24 h / Heating

8: 100 percent / NaOH / methanol / 4 h / Heating

With hydrogenchloride; potassium hydroxide; sodium hydroxide; copper(l) iodide; aluminium trichloride; diethylamine; cesium fluoride; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 3: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.08.018