N-(4-benzyloxycarbonylamidino-benzyl)-2-[(S)-4-dibenzylamino-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

Base Information

Chemical Name:N-(4-benzyloxycarbonylamidino-benzyl)-2-[(S)-4-dibenzylamino-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester
CAS No.:609846-93-7
Molecular Formula:C₃₆H₃₇N₅O₅
Molecular Weight:619.72
Hs Code.:

Synonyms:N-(4-benzyloxycarbonylamidino-benzyl)-2-[(S)-4-dibenzylamino-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

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Chemical Property of N-(4-benzyloxycarbonylamidino-benzyl)-2-[(S)-4-dibenzylamino-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

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Technology Process of N-(4-benzyloxycarbonylamidino-benzyl)-2-[(S)-4-dibenzylamino-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

There total 6 articles about N-(4-benzyloxycarbonylamidino-benzyl)-2-[(S)-4-dibenzylamino-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 441764-54-1
(S)-2-(2-oxo-ethoxy)-succinic acid dimethyl ester

: 609846-93-7
N-(4-benzyloxycarbonylamidino-benzyl)-2-[(S)-4-dibenzylamino-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / toluene / 65 °C

2: 100 percent / H₂ / Pd/C / tetrahydrofuran / 18 h

3: 77 percent / H₂O / 7 h / 60 °C

4: 60 percent / DIPEA; NaHCO₃; LiI / dimethylformamide / 7 h / 50 °C

5: aq. LiOH / methanol

6: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With lithium hydroxide; water; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0307990

Reference yield:

: (S)-[2-(tert-butoxycarbonyl-hydrazono)-ethoxy]-succinic acid dimethyl ester

: 609846-93-7
N-(4-benzyloxycarbonylamidino-benzyl)-2-[(S)-4-dibenzylamino-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂ / Pd/C / tetrahydrofuran / 18 h

2: 77 percent / H₂O / 7 h / 60 °C

3: 60 percent / DIPEA; NaHCO₃; LiI / dimethylformamide / 7 h / 50 °C

4: aq. LiOH / methanol

5: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With lithium hydroxide; water; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0307990

Reference yield:

: 609846-34-6
[(S)-4-amino-3-oxo-morpholin-2-yl]-acetic acid methyl ester

: 609846-93-7
N-(4-benzyloxycarbonylamidino-benzyl)-2-[(S)-4-dibenzylamino-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / DIPEA; NaHCO₃; LiI / dimethylformamide / 7 h / 50 °C

2: aq. LiOH / methanol

3: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With lithium hydroxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium iodide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0307990