Technology Process of 5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine
There total 5 articles about 5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(4-bromopyridin-2-yl)-1-(4-methoxyphenyl)ethanone oxime;
With
trifluoroacetic anhydride;
In
1,2-dimethoxyethane;
at 20 ℃;
for 0.666667h;
Inert atmosphere;
With
triethylamine;
In
1,2-dimethoxyethane; water;
at 0 ℃;
for 6.5h;
Inert atmosphere;
With
iron(II) chloride;
In
1,2-dimethoxyethane; water;
at 70 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium hexamethyldisilazane / tetrahydrofuran / 72 h / 0 - 20 °C
2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 48 h / 20 - 60 °C
3: triethylamine; trifluoroacetic anhydride / dichloromethane / 5.33 h / 0 - 20 °C
4: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 1 h / 175 °C
With
hydroxylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 48 h / 20 - 60 °C
2: triethylamine; trifluoroacetic anhydride / dichloromethane / 5.33 h / 0 - 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 1 h / 175 °C
With
hydroxylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride;
In
methanol; dichloromethane; 1,2-dichloro-ethane;
