2-formyl-6,7-dimethoxy-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 2-formyl-6,7-dimethoxy-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 371157-01-6
• Molecular Formula: C₁₉H₂₁NO₃
• Molecular Weight: 311.381
• Mol file: 371157-01-6.mol

Synonyms:2-formyl-6,7-dimethoxy-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 2-formyl-6,7-dimethoxy-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-formyl-6,7-dimethoxy-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline

There total 13 articles about 2-formyl-6,7-dimethoxy-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formyl acetic anhydride (2258-42-6) + N-2-(3,4-dimethoxyphenyl)ethyl-(1-phenylethylidene)amine (83100-97-4) → 2-formyl-6,7-dimethoxy-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (371157-01-6)

Guidance literature:

formyl acetic anhydride; N-2-(3,4-dimethoxyphenyl)ethyl-(1-phenylethylidene)amine; With formic acid; at 70 ℃; for 2h;

With trifluoroacetic acid; at 70 ℃; for 18h;

DOI:10.1248/cpb.50.253

Reference yield: 97.0%

2-formyl-6,7-dimethoxy-1-phenyl-1-phenylsulfanylmethyl-1,2,3,4-tetrahydroisoquinoline (371156-99-9) → 2-formyl-6,7-dimethoxy-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (371157-01-6)

Guidance literature:

With sodium tetrahydroborate; nickel dichloride; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

DOI:10.1248/cpb.49.979

Reference yield: 75.0%

N-[2-(3,4-dimethoxyphenyl)ethyl]-N-(1-phenylvinyl)formamide (473544-81-9) → 2-formyl-6,7-dimethoxy-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (371157-01-6)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 0.5h; Heating;

DOI:10.1248/cpb.50.253

upstream raw materials:

2-formyl-6,7-dimethoxy-1-phenyl-1-phenylsulfanylmethyl-1,2,3,4-tetrahydroisoquinoline

formyl acetic anhydride

N-2-(3,4-dimethoxyphenyl)ethyl-(1-phenylethylidene)amine

N-[2-(3,4-dimethoxyphenyl)ethyl]-N-(1-phenylvinyl)formamide