3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide

Base Information

Chemical Name:3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide
CAS No.:6403-51-6
Molecular Formula:C₁₈H₁₇NO₅
Molecular Weight:327.337
Hs Code.:
DSSTox Substance ID:DTXSID60367661
Wikidata:Q82153651

Synonyms:6403-51-6;3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide;DTXSID60367661;AKOS000623078;AB00107097-01

Suppliers and Price of 3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide

Chemical Property:

Vapor Pressure:6.14E-10mmHg at 25°C
Boiling Point:495°C at 760 mmHg
Flash Point:253.2°C
Density:1.103g/cm³
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:328.17869263
Heavy Atom Count:24
Complexity:349

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCOC1=CC(=CC(=C1)C(=O)NCC2=CN=CC=C2)OCCC

Technology Process of 3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide

There total 8 articles about 3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 7344-73-2
1-O-acetyllycorine

: 6403-51-6
(1S,3a1S,12bS)-2-oxo-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl acetate

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b02562

Reference yield: 77.0%

: 69787-57-1
(1S,2S,3a¹S,12bS)-2-chloro-2,3a¹,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]-phenanthridin-1-yl acetate

: 6403-51-6
(1S,3a1S,12bS)-2-oxo-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl acetate

Guidance literature:: (1S,2S,3a¹S,12bS)-2-chloro-2,3a¹,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]-phenanthridin-1-yl acetate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 3.05h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 ℃; Inert atmosphere;

Reference yield:

: 2492-05-9,75303-88-7,109647-12-3
1,2-diacetoxylycorine

: 6403-51-6
(1S,3a1S,12bS)-2-oxo-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / methanol / 1 h / 55 °C

2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 2 h / -78 °C

2.2: 0.17 h

With hydrogenchloride; oxalyl dichloride; dimethyl sulfoxide; In methanol; dichloromethane;
DOI:10.1002/cmdc.201300505