2-[1-[4-[(3,4-dichlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:2-[1-[4-[(3,4-dichlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid
CAS No.:1233248-12-8
Molecular Formula:C₂₅H₁₆Cl₂N₂O₄
Molecular Weight:479.319
Hs Code.:

Synonyms:2-[1-[4-[(3,4-dichlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

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Chemical Property of 2-[1-[4-[(3,4-dichlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

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Technology Process of 2-[1-[4-[(3,4-dichlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

There total 13 articles about 2-[1-[4-[(3,4-dichlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1374249-87-2
C₂₆H₁₈Cl₂N₂O₄

: 1233248-12-8
2-[1-[4-[(3,4-dichlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: With methanol; water; sodium hydroxide; at 0 ℃;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: C₂₂H₁₈ClNO₄

: 1233248-12-8
2-[1-[4-[(3,4-dichlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; acetonitrile

1.2: 20 °C

2.1: diazomethyl-trimethyl-silane / 20 °C

3.1: trifluoroacetic acid / chloroform / 0 - 50 °C

4.1: oxalyl dichloride / chloroform; N,N-dimethyl-formamide / 20 °C

5.1: pyridine / chloroform / 0 - 20 °C

6.1: methanol; water; sodium hydroxide / 0 °C

With pyridine; methanol; oxalyl dichloride; water; trifluoroacetic acid; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetonitrile; 1.2: Wolff rearrangement;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1233249-58-5
1-{[4-(tert-butoxycarbonyl)phenyl]carbonyl)isoquinoline-4-carboxylic acid

: 1233248-12-8
2-[1-[4-[(3,4-dichlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / chloroform / 20 °C

2.1: tetrahydrofuran; acetonitrile

2.2: 20 °C

3.1: diazomethyl-trimethyl-silane / 20 °C

4.1: trifluoroacetic acid / chloroform / 0 - 50 °C

5.1: oxalyl dichloride / chloroform; N,N-dimethyl-formamide / 20 °C

6.1: pyridine / chloroform / 0 - 20 °C

7.1: methanol; water; sodium hydroxide / 0 °C

With pyridine; methanol; oxalyl dichloride; water; trifluoroacetic acid; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetonitrile; 2.2: Wolff rearrangement;
DOI:10.1016/j.bmcl.2012.03.009