1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid tert-butyl ester

Base Information

Chemical Name:1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid tert-butyl ester
CAS No.:1455091-96-9
Molecular Formula:C₂₇H₂₅F₂N₃O₅
Molecular Weight:509.509
Hs Code.:

Synonyms:1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid tert-butyl ester

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Chemical Property of 1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid tert-butyl ester

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Technology Process of 1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid tert-butyl ester

There total 8 articles about 1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1366068-12-3
1-(aminomethyl)cyclobutanecarboxylic acid tert-butyl ester

: 1455091-69-6
1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester

: 1455091-96-9
1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid tert-butyl ester

Guidance literature:: In ethanol; at 140 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1366068-08-7
1-cyano-cyclobutanecarboxylic acid tert-butyl ester

: 1455091-96-9
1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / methanol / 20 °C

2: ethanol / 1 h / 140 °C / Microwave irradiation

With hydrogen; In methanol; ethanol;

Reference yield:

: 1116-98-9
cyanoacetic acid tert-butyl ester

: 1455091-96-9
1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

2: hydrogen / methanol / 20 °C

3: ethanol / 1 h / 140 °C / Microwave irradiation

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; ethanol; N,N-dimethyl-formamide;