ethyl 2-(2-(((2,4,6-trimethoxybenzyl)amino)methyl)acrylamido)acetate

Base Information

• Chemical Name: ethyl 2-(2-(((2,4,6-trimethoxybenzyl)amino)methyl)acrylamido)acetate
• CAS No.: 1312771-15-5
• Molecular Formula: C₁₈H₂₆N₂O₆
• Molecular Weight: 366.414
• Mol file: 1312771-15-5.mol

Synonyms:ethyl 2-(2-(((2,4,6-trimethoxybenzyl)amino)methyl)acrylamido)acetate

Chemical Property of ethyl 2-(2-(((2,4,6-trimethoxybenzyl)amino)methyl)acrylamido)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(2-(((2,4,6-trimethoxybenzyl)amino)methyl)acrylamido)acetate

There total 2 articles about ethyl 2-(2-(((2,4,6-trimethoxybenzyl)amino)methyl)acrylamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,6-trimethoxybenzaldehyde (830-79-5) + C8H14N2O3 → ethyl 2-(2-(((2,4,6-trimethoxybenzyl)amino)methyl)acrylamido)acetate (1312771-15-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; triethylamine; In ethanol; at 40 ℃; for 1.5h; Cooling with ice;

Reference yield:

ethyl 2-(2-{[di(tert-butoxycarbonyl)amino]methyl}acrylamide)acetate (1312771-14-4) → ethyl 2-(2-(((2,4,6-trimethoxybenzyl)amino)methyl)acrylamido)acetate (1312771-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanesulfonic acid / ethanol / 17 h / 40 °C

1.2: Cooling with ice

2.1: triethylamine; sodium tris(acetoxy)borohydride / ethanol / 1.5 h / 40 °C / Cooling with ice

With methanesulfonic acid; sodium tris(acetoxy)borohydride; triethylamine; In ethanol;

Reference yield:

ethyl 2-(2-(((2,4,6-trimethoxybenzyl)amino)methyl)acrylamido)acetate (1312771-15-5) → C16H22N2O6

Guidance literature:

ethyl 2-(2-(((2,4,6-trimethoxybenzyl)amino)methyl)acrylamido)acetate; With water; sodium hydroxide; In methanol; at 20 ℃; for 14h;

With potassium hydrogensulfate; In methanol; water; pH=4.9;

upstream raw materials:

2,4,6-trimethoxybenzaldehyde

ethyl 2-(2-{[di(tert-butoxycarbonyl)amino]methyl}acrylamide)acetate

Downstream raw materials:

6-methylene-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

6-[4-chloro-3-(trifluoromethyl)benzyl]-1-(2,4,6-trimethoxybenzyl)-1,4-diazepan-2,5-dione