diethyl 2-(allylamino)-2-(4-(4-chlorophenyl)but-3-ynyl)malonate

Base Information

Chemical Name:diethyl 2-(allylamino)-2-(4-(4-chlorophenyl)but-3-ynyl)malonate
CAS No.:1374023-97-8
Molecular Formula:C₂₀H₂₄ClNO₄
Molecular Weight:377.868
Hs Code.:

Synonyms:diethyl 2-(allylamino)-2-(4-(4-chlorophenyl)but-3-ynyl)malonate

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Chemical Property of diethyl 2-(allylamino)-2-(4-(4-chlorophenyl)but-3-ynyl)malonate

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Technology Process of diethyl 2-(allylamino)-2-(4-(4-chlorophenyl)but-3-ynyl)malonate

There total 5 articles about diethyl 2-(allylamino)-2-(4-(4-chlorophenyl)but-3-ynyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₀ClNO₄

: 106-95-6
allyl bromide

: 1374023-97-8
diethyl 2-(allylamino)-2-(4-(4-chlorophenyl)but-3-ynyl)malonate

Guidance literature:: With lithium hydroxide monohydrate; In N,N-dimethyl-formamide; at 40 ℃; for 12h; Inert atmosphere;
DOI:10.1002/adsc.201100922

Reference yield:

: C₂₂H₂₈ClNO₆

: 1374023-97-8
diethyl 2-(allylamino)-2-(4-(4-chlorophenyl)but-3-ynyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

2: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 12 h / 40 °C / Inert atmosphere

With lithium hydroxide monohydrate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201100922

Reference yield:

: 52999-16-3
4-(4’-chlorophenyl)-4-butyn-1-ol

: 1374023-97-8
diethyl 2-(allylamino)-2-(4-(4-chlorophenyl)but-3-ynyl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

2.2: 12.5 h / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 12 h / 40 °C / Inert atmosphere

With pyridine; lithium hydroxide monohydrate; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/adsc.201100922