diethyl 5,5'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-acetyl-3-(4-chlorophenyl)-5-oxopentanoate)

Base Information

• Chemical Name: diethyl 5,5'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-acetyl-3-(4-chlorophenyl)-5-oxopentanoate)
• CAS No.: 1447968-12-8
• Molecular Formula: C₃₈H₄₃Cl₂NO₈
• Molecular Weight: 712.667

Synonyms:diethyl 5,5'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-acetyl-3-(4-chlorophenyl)-5-oxopentanoate)

Chemical Property of diethyl 5,5'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-acetyl-3-(4-chlorophenyl)-5-oxopentanoate)

Chemical Property:

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Technology Process of diethyl 5,5'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-acetyl-3-(4-chlorophenyl)-5-oxopentanoate)

There total 3 articles about diethyl 5,5'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-acetyl-3-(4-chlorophenyl)-5-oxopentanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(2E,2'E)-1,1'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(3-(4-chlorophenyl)prop-2-en-1-one) (1447967-99-8) + ethyl acetoacetate (141-97-9) → diethyl 5,5'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-acetyl-3-(4-chlorophenyl)-5-oxopentanoate) (1447968-12-8)

Guidance literature:

With sodium ethanolate; In ethanol; for 6h; Reflux;

DOI:10.1016/j.saa.2012.12.069

Reference yield:

3,5-diacetyl-1,4-dihydro-2,4,6-trimethylpyridine (1081-09-0) → diethyl 5,5'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-acetyl-3-(4-chlorophenyl)-5-oxopentanoate) (1447968-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / 20 °C

2: sodium ethanolate / ethanol / 6 h / Reflux

With sodium ethanolate; potassium hydroxide; In ethanol; 2: |Michael Addition;

DOI:10.1016/j.saa.2012.12.069

Reference yield:

4-chlorobenzaldehyde (104-88-1) → diethyl 5,5'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-acetyl-3-(4-chlorophenyl)-5-oxopentanoate) (1447968-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / 20 °C

2: sodium ethanolate / ethanol / 6 h / Reflux

With sodium ethanolate; potassium hydroxide; In ethanol; 2: |Michael Addition;

DOI:10.1016/j.saa.2012.12.069

upstream raw materials:

(2E,2'E)-1,1'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(3-(4-chlorophenyl)prop-2-en-1-one)

ethyl acetoacetate

3,5-diacetyl-1,4-dihydro-2,4,6-trimethylpyridine

4-chlorobenzaldehyde

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