(3R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile

Base Information

• Chemical Name: (3R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile
• CAS No.: 195299-16-2
• Molecular Formula: C₁₉H₂₆N₂O₃
• Molecular Weight: 330.427

Synonyms:(3R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile

Chemical Property of (3R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile

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Technology Process of (3R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile

There total 2 articles about (3R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-cyano-5-oxazolopyrrolidine (195299-15-1) + Bromoacetaldehyde diethyl acetal (2032-35-1) → (3R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile (195299-16-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;

DOI:10.1021/jo971122l

Reference yield:

Bromoacetaldehyde diethyl acetal (2032-35-1) + (3R,5R,7aS)-3-Phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile → (3R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile (195299-16-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; Yield given. Multistep reaction; 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 4 h;

DOI:10.1021/jo960398a

Reference yield: 100.0%

(3R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile (195299-16-2) → 2-[2-(2,2-diethoxyethyl)pyrrolidin-1-yl]-2-phenylethanol (178625-94-0)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 2h; Heating;

DOI:10.1021/jo960398a

upstream raw materials:

Bromoacetaldehyde diethyl acetal

2-cyano-5-oxazolopyrrolidine

Downstream raw materials:

2-[2-(2,2-diethoxyethyl)pyrrolidin-1-yl]-2-phenylethanol

(3R,5R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole

(E)-5-((3R,5R,7aS)-3-Phenyl-hexahydro-pyrrolo[2,1-b]oxazol-5-yl)-pent-3-en-2-one

1-[(1S,5R)-3-Chloro-8-((R)-2-hydroxy-1-phenyl-ethyl)-8-aza-bicyclo[3.2.1]oct-2-yl]-ethanone

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