3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carbomethoxypropionsaeuremethylester

Base Information

• Chemical Name: 3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carbomethoxypropionsaeuremethylester
• CAS No.: 104143-91-1
• Molecular Formula: C₂₅H₂₅NO₄
• Molecular Weight: 403.478
• Mol file: 104143-91-1.mol

Synonyms:3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carbomethoxypropionsaeuremethylester

Chemical Property of 3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carbomethoxypropionsaeuremethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carbomethoxypropionsaeuremethylester

There total 2 articles about 3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carbomethoxypropionsaeuremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-methylidenmalonsaeuredimethylester (104143-90-0) → 3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carbomethoxypropionsaeuremethylester (104143-91-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; Ambient temperature;

DOI:10.1002/ardp.19863190308

Reference yield:

dimethyl (methoxymethylene)malonate (22398-14-7) → 3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carbomethoxypropionsaeuremethylester (104143-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 11 percent / xylene; 1,2-dimethoxy-ethane / 72 h / Heating

2: 80 percent / H₂ / 5percent Pd/C / ethyl acetate / Ambient temperature

With hydrogen; palladium on activated charcoal; In 1,2-dimethoxyethane; ethyl acetate; xylene;

DOI:10.1002/ardp.19863190308

Reference yield: 91.0%

3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carbomethoxypropionsaeuremethylester (104143-91-1) → 3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carboxypropionsaeure (104143-92-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 4h; Heating;

DOI:10.1002/ardp.19863190308

upstream raw materials:

(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-methylidenmalonsaeuredimethylester

dimethyl (methoxymethylene)malonate

Downstream raw materials:

3-(6,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-carboxypropionsaeure