ethyl 2-acetylamino-2-cyano-3-(4-nitrophenyl)-5-oxo-5-(4-fluorophenyl)pentanoate

Base Information

Chemical Name:ethyl 2-acetylamino-2-cyano-3-(4-nitrophenyl)-5-oxo-5-(4-fluorophenyl)pentanoate
CAS No.:727678-31-1
Molecular Formula:C₂₂H₂₀FN₃O₆
Molecular Weight:441.416
Hs Code.:

Synonyms:ethyl 2-acetylamino-2-cyano-3-(4-nitrophenyl)-5-oxo-5-(4-fluorophenyl)pentanoate

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Chemical Property of ethyl 2-acetylamino-2-cyano-3-(4-nitrophenyl)-5-oxo-5-(4-fluorophenyl)pentanoate

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Technology Process of ethyl 2-acetylamino-2-cyano-3-(4-nitrophenyl)-5-oxo-5-(4-fluorophenyl)pentanoate

There total 2 articles about ethyl 2-acetylamino-2-cyano-3-(4-nitrophenyl)-5-oxo-5-(4-fluorophenyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 102692-41-1
(E)-1-(4-fluorophenyl)-3-(4-nitrophenyl)-2-propen-1-one

: 90877-70-6,4977-62-2
ethyl 2-acetamido-2-cyanoacetate

: 727678-31-1
ethyl 2-acetylamino-2-cyano-3-(4-nitrophenyl)-5-oxo-5-(4-fluorophenyl)pentanoate

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1055/s-2004-822325

Reference yield:

: 3849-21-6
ethyl cyanoglyoxylate-2-oxime

: 727678-31-1
ethyl 2-acetylamino-2-cyano-3-(4-nitrophenyl)-5-oxo-5-(4-fluorophenyl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 41 g / HOAc; Zn / diethyl ether / 1 h

2: 93 percent / t-BuONa / tetrahydrofuran / 0.5 h / 20 °C

With acetic acid; sodium t-butanolate; zinc; In tetrahydrofuran; diethyl ether; 2: Michael addition;
DOI:10.1055/s-2004-822325

Reference yield:

: 727678-31-1
ethyl 2-acetylamino-2-cyano-3-(4-nitrophenyl)-5-oxo-5-(4-fluorophenyl)pentanoate

: ethyl 1,2-dihydro-4-(4-nitrophenyl)-6-(4-fluorophenyl)-2-oxo-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / aq. HCl / acetic acid / 20 °C

2: 66 percent / aq. Na₂CO₃ / dimethylsulfoxide / 1 h / 140 °C

With hydrogenchloride; sodium carbonate; In acetic acid; dimethyl sulfoxide;
DOI:10.1055/s-2004-822325