4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-[2-(piperazin-1-yl)-ethoxy]-quinazoline

Base Information

• Chemical Name: 4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-[2-(piperazin-1-yl)-ethoxy]-quinazoline
• CAS No.: 402573-20-0
• Molecular Formula: C₂₅H₂₉ClFN₅O₂
• Molecular Weight: 485.989

Synonyms:4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-[2-(piperazin-1-yl)-ethoxy]-quinazoline

Chemical Property of 4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-[2-(piperazin-1-yl)-ethoxy]-quinazoline

Chemical Property:

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Technology Process of 4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-[2-(piperazin-1-yl)-ethoxy]-quinazoline

There total 1 articles about 4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-[2-(piperazin-1-yl)-ethoxy]-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-{2-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]-ethoxy}-quinazoline (402573-21-1) → 4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-[2-(piperazin-1-yl)-ethoxy]-quinazoline (402573-20-0)

Guidance literature:

With ammonia; trifluoroacetic acid; In dichloromethane; water;

Reference yield:

4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-[2-(piperazin-1-yl)-ethoxy]-quinazoline (402573-20-0) + (R)-5-(methanesulfonyloxymethyl)dihydrofuran-2(3H)-one (102774-94-7) → 4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-(2-{4-[(R)-(2-oxo-tetrahydrofuran-5-yl)methyl]-piperazin-1-yl}-ethoxy)-quinazoline (402573-54-0)

Guidance literature:

With sodium iodide; potassium carbonate; In acetonitrile;

Reference yield:

4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-[2-(piperazin-1-yl)-ethoxy]-quinazoline (402573-20-0) + 3-bromofuranone (365532-34-9) → 4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-{2-[4-(2-oxo-tetrahydrofuran-3-yl)-piperazin-1-yl]-ethoxy}-quinazoline (402573-48-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; methanol;

upstream raw materials:

4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-{2-[4-(tert-butyloxycarbonyl)-piperazin-1-yl]-ethoxy}-quinazoline

Downstream raw materials:

4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-(2-{4-[(R)-(2-oxo-tetrahydrofuran-5-yl)methyl]-piperazin-1-yl}-ethoxy)-quinazoline

4-[(3-chloro-4-fluorophenyl)amino]-6-cyclopentyloxy-7-{2-[4-(2-oxo-tetrahydrofuran-3-yl)-piperazin-1-yl]-ethoxy}-quinazoline

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