Tetrahydrocortisone

Base Information

Chemical Name:Tetrahydrocortisone
CAS No.:53-05-4
Molecular Formula:C21H32 O5
Molecular Weight:364.482
Hs Code.:
European Community (EC) Number:200-161-9
NSC Number:76984
UNII:5HF9TM2D15
DSSTox Substance ID:DTXSID70878591
Nikkaji Number:J4.138F
Wikipedia:Tetrahydrocortisone
Wikidata:Q7706546
Metabolomics Workbench ID:49820
ChEMBL ID:CHEMBL1908043
Mol file:53-05-4.mol

Synonyms:Tetrahydrocortisone

Suppliers and Price of Tetrahydrocortisone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TetrahydroCortisone
5mg
$ 175.00

Medical Isotopes, Inc.
3β,5β-TetrahydroCortisone
50 mg
$ 3000.00

ChemScene
Tetrahydrocortisone ≥99.0%
5mg
$ 530.00

American Custom Chemicals Corporation
TETRAHYDROCORTISONE 95.00%
5MG
$ 495.99

Total 19 raw suppliers

Chemical Property of Tetrahydrocortisone

Chemical Property:

Melting Point:190°
Refractive Index:1.6120 (estimate)
Boiling Point:544.5°Cat760mmHg
PKA:12.38±0.70(Predicted)
Flash Point:297.1°C
PSA：94.83000
Density:1.249g/cm³
LogP:1.86150
Storage Temp.:Refrigerator
Solubility.:Ethanol (Slightly), Methanol (Slightly)
XLogP3:2.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:364.22497412
Heavy Atom Count:26
Complexity:632

Purity/Quality:

99% ^*data from raw suppliers

TetrahydroCortisone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCC(CC1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C)O
Isomeric SMILES:C[C@]12CC[C@H](C[C@H]1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
Recent ClinicalTrials:Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy
Uses Cortisone (C696500) derivative. A normal mammalian metabolite of Cortisone (C696500).

Technology Process of Tetrahydrocortisone

There total 12 articles about Tetrahydrocortisone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95044-38-5
21-bromo-3α,17-dihydroxy-5β-pregnane-11,20-dione

: 53-05-4
tetrahydrocortisone

Guidance literature:: With sodium hydroxide;
DOI:10.1021/ja01122a060

Reference yield:

: 641-78-1
3α,17-dihydroxy-5β-pregnane-11,20-dione

: 53-05-4
tetrahydrocortisone

Guidance literature:: Multi-step reaction with 2 steps

1: dioxane; bromine

2: aq.-ethanolic NaOH

With 1,4-dioxane; sodium hydroxide; bromine;
DOI:10.1021/ja01122a060

Reference yield:

: 115484-65-6
(17Ξ)-3α,11,20-triacetoxy-5β-pregna-9(11),17(20)-diene

: 53-05-4
tetrahydrocortisone

Guidance literature:: Multi-step reaction with 3 steps

1: peroxybenzoic acid; benzene / Behandeln des Reaktionsprodukts mit wss.-aethanol.NaOH

2: dioxane; bromine

3: aq.-ethanolic NaOH

With 1,4-dioxane; sodium hydroxide; Perbenzoic acid; bromine; benzene;
DOI:10.1021/ja01122a060