3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propan-1-one

Base Information

Chemical Name:3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propan-1-one
CAS No.:212578-62-6
Molecular Formula:C₂₈H₃₀FN₃O₂
Molecular Weight:459.564
Hs Code.:

Synonyms:3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propan-1-one

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Chemical Property of 3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propan-1-one

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Technology Process of 3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propan-1-one

There total 3 articles about 3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 212578-60-4
3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)propionic acid

: 212578-62-6
3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propan-1-one

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jm970795t

Reference yield:

: (E)-3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-acrylic acid ethyl ester

: 212578-62-6
3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / Raney Ni / ethanol; H₂O / 4 h / 20 °C / 2585.7 Torr

2: 98 percent / KOH / ethanol / Heating

3: 97 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

With potassium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel; In ethanol; dichloromethane; water;
DOI:10.1021/jm970795t

Reference yield:

: 212578-72-8
3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)propionic acid ethyl ester

: 212578-62-6
3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / KOH / ethanol / Heating

2: 97 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/jm970795t