L-(2,4-dimethoxy-3-methyl-5-tert-butyldimethylsiloxy)phenylalanine tert-butyl ester

Base Information

Chemical Name:L-(2,4-dimethoxy-3-methyl-5-tert-butyldimethylsiloxy)phenylalanine tert-butyl ester
CAS No.:912655-01-7
Molecular Formula:C₂₂H₃₉NO₅Si
Molecular Weight:425.641
Hs Code.:

Synonyms:L-(2,4-dimethoxy-3-methyl-5-tert-butyldimethylsiloxy)phenylalanine tert-butyl ester

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Chemical Property of L-(2,4-dimethoxy-3-methyl-5-tert-butyldimethylsiloxy)phenylalanine tert-butyl ester

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Technology Process of L-(2,4-dimethoxy-3-methyl-5-tert-butyldimethylsiloxy)phenylalanine tert-butyl ester

There total 4 articles about L-(2,4-dimethoxy-3-methyl-5-tert-butyldimethylsiloxy)phenylalanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₄₇NO₅Si

: 912655-01-7
L-(2,4-dimethoxy-3-methyl-5-tert-butyldimethylsiloxy)phenylalanine tert-butyl ester

Guidance literature:: With water; In tetrahydrofuran; acetic acid; at 20 ℃; for 6h; optical yield given as %ee; chemoselective reaction; Inert atmosphere;
DOI:10.1021/jo8027449

Reference yield:

: C₂₂H₃₇NO₅Si

: 912655-01-7
L-(2,4-dimethoxy-3-methyl-5-tert-butyldimethylsiloxy)phenylalanine tert-butyl ester

Guidance literature:: With acetic acid; In tetrahydrofuran; water;
DOI:10.1055/s-2006-944225

Reference yield:

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 912655-01-7
L-(2,4-dimethoxy-3-methyl-5-tert-butyldimethylsiloxy)phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: O-⁽⁹⁾-allyl-N-(9'-anthracenylmethyl)cinchonidium bromide; CsOH*H₂O / CH₂Cl₂ / -78 °C

2: AcOH / tetrahydrofuran; H₂O

With cesium hydroxide; acetic acid; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1055/s-2006-944225