(2S,3E)-1-[(3S)-4-benzyl-2-thioxothiazolidin-3-yl]-5-chloro-4-iodo-2-methylpent-3-en-1-one

Base Information

• Chemical Name: (2S,3E)-1-[(3S)-4-benzyl-2-thioxothiazolidin-3-yl]-5-chloro-4-iodo-2-methylpent-3-en-1-one
• CAS No.: 1374301-46-8
• Molecular Formula: C₁₆H₁₇ClINOS₂
• Molecular Weight: 465.807

Synonyms:(2S,3E)-1-[(3S)-4-benzyl-2-thioxothiazolidin-3-yl]-5-chloro-4-iodo-2-methylpent-3-en-1-one

Chemical Property of (2S,3E)-1-[(3S)-4-benzyl-2-thioxothiazolidin-3-yl]-5-chloro-4-iodo-2-methylpent-3-en-1-one

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Technology Process of (2S,3E)-1-[(3S)-4-benzyl-2-thioxothiazolidin-3-yl]-5-chloro-4-iodo-2-methylpent-3-en-1-one

There total 1 articles about (2S,3E)-1-[(3S)-4-benzyl-2-thioxothiazolidin-3-yl]-5-chloro-4-iodo-2-methylpent-3-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

C16H17ClINO4S3 → (2S,3E)-1-[(3S)-4-benzyl-2-thioxothiazolidin-3-yl]-5-chloro-4-iodo-2-methylpent-3-en-1-one (1374301-46-8) + (2S,3E)-1-[(3S)-4-benzyl-2-thioxothiazolidin-3-yl]-5-chloro-4-iodo-2-methylpent-3-en-1-one (1374301-55-9)

Guidance literature:

With triethylamine; In diethyl ether; pentane; at -78 ℃; for 0.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201101430

Reference yield: 64.0%

(2S,3E)-1-[(3S)-4-benzyl-2-thioxothiazolidin-3-yl]-5-chloro-4-iodo-2-methylpent-3-en-1-one (1374301-46-8) + (R)-2-Hydroxy-2-(S)-pyrrolidin-2-yl-propionic acid methyl ester (192655-94-0) → methyl (2R)-2-[(2S)-1-{(2E,4S)-5-[(4S)-4-benzyl-2-thioxothiazolidin-3-yl]-2-iodo-4-methyl-5-oxopent-2-enyl}pyrrolidin-2-yl]-2-hydroxypropanoate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/ejoc.201101430

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