methyl 2-[4-[[6-(3-chlorophenyl)-3-ethyl-2-methyl-4-pyridyl]amino]phenyl]acetate

Base Information

Chemical Name:methyl 2-[4-[[6-(3-chlorophenyl)-3-ethyl-2-methyl-4-pyridyl]amino]phenyl]acetate
CAS No.:1606976-46-8
Molecular Formula:C₂₃H₂₃ClN₂O₂
Molecular Weight:394.901
Hs Code.:

Synonyms:methyl 2-[4-[[6-(3-chlorophenyl)-3-ethyl-2-methyl-4-pyridyl]amino]phenyl]acetate

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Chemical Property of methyl 2-[4-[[6-(3-chlorophenyl)-3-ethyl-2-methyl-4-pyridyl]amino]phenyl]acetate

Chemical Property:

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Technology Process of methyl 2-[4-[[6-(3-chlorophenyl)-3-ethyl-2-methyl-4-pyridyl]amino]phenyl]acetate

There total 8 articles about methyl 2-[4-[[6-(3-chlorophenyl)-3-ethyl-2-methyl-4-pyridyl]amino]phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1606976-45-7
4-chloro-6-(3-chlorophenyl)-3-ethyl-2-methyl-pyridine hydrochloride

: 39552-81-3
methyl p-aminophenylacetate

: 1606976-46-8
methyl 2-[4-[[6-(3-chlorophenyl)-3-ethyl-2-methyl-4-pyridyl]amino]phenyl]acetate

Guidance literature:: at 150 ℃; for 1h; Inert atmosphere;

Reference yield:

: 42805-39-0
ethyl (Z)-3-amino-2-ethyl-but-2-enoate

: 1606976-46-8
methyl 2-[4-[[6-(3-chlorophenyl)-3-ethyl-2-methyl-4-pyridyl]amino]phenyl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

2.1: sodium methylate / ethanol; methanol / 1 h / Reflux

3.1: hydrogenchloride / water / Reflux

3.2: 20 °C / pH 7

4.1: trichlorophosphate / 90 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol; water / 3 h / 90 °C / Inert atmosphere

6.1: 1 h / 150 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; water; toluene;

Reference yield:

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 1606976-46-8
methyl 2-[4-[[6-(3-chlorophenyl)-3-ethyl-2-methyl-4-pyridyl]amino]phenyl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium acetate; ammonia; sodium sulfate / ethanol; methanol / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

3.1: sodium methylate / ethanol; methanol / 1 h / Reflux

4.1: hydrogenchloride / water / Reflux

4.2: 20 °C / pH 7

5.1: trichlorophosphate / 90 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol; water / 3 h / 90 °C / Inert atmosphere

7.1: 1 h / 150 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; ammonia; sodium methylate; potassium carbonate; sodium sulfate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; water; toluene;