[3S,5R]-S-(1-phenyl-1H-tetrazol-5-yl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-thiol

Base Information

Chemical Name:[3S,5R]-S-(1-phenyl-1H-tetrazol-5-yl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-thiol
CAS No.:440104-15-4
Molecular Formula:C₂₃H₃₀N₄O₂S
Molecular Weight:426.583
Hs Code.:

Synonyms:[3S,5R]-S-(1-phenyl-1H-tetrazol-5-yl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-thiol

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Chemical Property of [3S,5R]-S-(1-phenyl-1H-tetrazol-5-yl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-thiol

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Technology Process of [3S,5R]-S-(1-phenyl-1H-tetrazol-5-yl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-thiol

There total 12 articles about [3S,5R]-S-(1-phenyl-1H-tetrazol-5-yl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 440104-14-3
[3S,5R]-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 440104-15-4
[3S,5R]-S-(1-phenyl-1H-tetrazol-5-yl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-thiol

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
DOI:10.1021/ol025872f

Reference yield:

: 440104-13-2
[3S,5R]-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexanal

: 440104-15-4
[3S,5R]-S-(1-phenyl-1H-tetrazol-5-yl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-thiol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaBH₄ / methanol / 0.75 h / 0 - 20 °C

2: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C

With sodium tetrahydroborate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;
DOI:10.1021/ol025872f

Reference yield:

: 440104-12-1
[3S,5R]-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexanenitrile

: 440104-15-4
[3S,5R]-S-(1-phenyl-1H-tetrazol-5-yl)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-thiol

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / DIBAL-H / CH₂Cl₂; toluene / 4 h / -78 °C

2: 100 percent / NaBH₄ / methanol / 0.75 h / 0 - 20 °C

3: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C

With sodium tetrahydroborate; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ol025872f