Metaraminol

Base Information Edit

Chemical Name:Metaraminol
CAS No.:54-49-9
Molecular Formula:C₉H₁₃NO₂
Molecular Weight:167.208
Hs Code.:
UNII:818U2PZ2EH
DSSTox Substance ID:DTXSID8023268
Nikkaji Number:J4.155F
Wikipedia:Metaraminol,Meta-Hydroxynorephedrine
Wikidata:Q409981
NCI Thesaurus Code:C61835
Pharos Ligand ID:Y97XU36YY6XW
Metabolomics Workbench ID:42939
ChEMBL ID:CHEMBL1201319
Mol file:54-49-9.mol

Synonyms:Aramine;Araminol;Bitartrate, Metaraminol;hydroxyphenylpropanolamine;Isophenylephrine;m Hydroxynorephedrine;m Hydroxyphenylpropanolamine;m-Hydroxynorephedrine;m-hydroxyphenylpropanolamine;meta Hydroxynorephedrine;meta-Hydroxynorephedrine;Metaradrin;Metaraminol;Metaraminol Bitartrate;Metaraminol Bitartrate (1:1);Metaraminol Tartrate;Tartrate, Metaraminol

Suppliers and Price of Metaraminol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METARAMINOL 95.00%
5MG
$ 501.28

Total 22 raw suppliers

Chemical Property of Metaraminol Edit

Chemical Property:

Melting Point:107.5°C
Refractive Index:1.4760 (estimate)
Boiling Point:357.9°Cat760mmHg
PKA:pKa 8.6 (Uncertain)
Flash Point:170.3°C
PSA：66.48000
Density:1.198g/cm³
LogP:1.47310
XLogP3:-0.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:167.094628657
Heavy Atom Count:12
Complexity:141

Purity/Quality:

99% ^*data from raw suppliers

METARAMINOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(C1=CC(=CC=C1)O)O)N
Isomeric SMILES:C[C@@H]([C@@H](C1=CC(=CC=C1)O)O)N
Recent ClinicalTrials:Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery
Recent EU Clinical Trials:An assessment of the effects of pressors on graft blood flow after free tissue transfer surgery: A randomised study – Part II
Uses Metaraminol is a sympathomimetic amine of both direct and indirect action that has hemodynamic characteristics similar to norepinephrine. It has the ability to elevate both systolic and diastolic blood pressure. It is used in hypotensive shock for the purpose of elevating blood pressure, which can result from spinal anesthesia, surgical complications, and head trauma. Adrenergic. Metaraminol is a direct and indirect non-specific adrenoceptor agonist. It acts primarily via α1-receptors, causing vasoconstriction with subsequent increase in arterial pressure and reflex bradycardia. It is administered via i.v. bolus injection at a dose of 0.5–2 mg, titrated to effect.
Therapeutic Function Hypertensive
Clinical Use #N/A
Drug interactions Potentially hazardous interactions with other drugs Adrenergic neurone blockers: hypotensive effect antagonised. Anaesthetics: risk of ventricular arrhythmias with isoflurane - avoid. Antibacterials: risk of hypertensive crisis with linezolid and tedizolid - avoid for at least 2 weeks after stopping linezolid and tedizolid. Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide - avoid for at least 2 weeks after stopping MAOIs. Dopaminergics: avoid with rasagiline and selegiline

Technology Process of Metaraminol

There total 16 articles about Metaraminol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%