(-)-aplaminal

Base Information

• Chemical Name: (-)-aplaminal
• CAS No.: 1005010-20-7
• Molecular Formula: C₁₆H₁₉N₃O₅
• Molecular Weight: 333.344
• Mol file: 1005010-20-7.mol

Synonyms:(-)-aplaminal

Chemical Property of (-)-aplaminal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-aplaminal

There total 5 articles about (-)-aplaminal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C22H22N4O7 → (-)-aplaminal (1005010-20-7)

Guidance literature:

With 2,2,2-trifluoroethanol; at 20 ℃; for 24h; UV-irradiation;

DOI:10.1039/c9nj04743c

Reference yield: 66.0%

C17H23N3O6 (1060729-67-0) → (-)-aplaminal (1005010-20-7)

Guidance literature:

With trimethylaluminum; In hexane; toluene; at 100 ℃; for 21h; Inert atmosphere;

DOI:10.1021/ol801794f

Reference yield:

C21H23N5O10S → (-)-aplaminal (1005010-20-7)

Guidance literature:

Multi-step reaction with 4 steps

1: thiophenol; potassium carbonate / acetonitrile / 3.5 h / 0 - 20 °C

2: potassium carbonate / methanol / 15 h / 20 °C

3: bis(dibenzylideneacetone)-palladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate / toluene / 24 h / Inert atmosphere; Reflux

4: 2,2,2-trifluoroethanol / 24 h / 20 °C / UV-irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 2,2,2-trifluoroethanol; potassium carbonate; caesium carbonate; thiophenol; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; toluene; acetonitrile; 3: |Buchwald-Hartwig Coupling;

DOI:10.1039/c9nj04743c

upstream raw materials:

C₁₇H₂₃N₃O₆