6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Base Information

Chemical Name:6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid
CAS No.:133166-46-8
Molecular Formula:C₁₇H₁₁Br₂FN₂O₄
Molecular Weight:486.092
Hs Code.:

Synonyms:6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Suppliers and Price of 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

There total 3 articles about 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.5%

: 133166-97-9
6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester

: 133166-46-8
6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; for 0.5h;
DOI:10.1021/jm00108a038

Reference yield:

: 4692-98-2
5-bromoisatoic anhydride

: 133166-46-8
6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH (80percent dispersion in mineral oil) / 1.) DMF, 2 h, 2.) 8 h

2: 87.6 percent / Et₃N / toluene / 4 h / 100 °C

3: 57.1 percent / toluene / 4 h / 90 °C

4: 67.5 percent / 2.5 N aq. NaOH / methanol; tetrahydrofuran / 0.5 h

With sodium hydroxide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm00108a038

Reference yield:

: 133166-94-6
N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester

: 133166-46-8
6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 57.1 percent / toluene / 4 h / 90 °C

2: 67.5 percent / 2.5 N aq. NaOH / methanol; tetrahydrofuran / 0.5 h

With sodium hydroxide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm00108a038