4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid

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Chemical Name:4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid
CAS No.:121653-85-8
Molecular Formula:C₂₀H₂₅N₃O₇
Molecular Weight:419.434
Hs Code.:

Synonyms:4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid

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Chemical Property of 4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid

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Technology Process of 4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid

There total 6 articles about 4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 121653-84-7
methyl 4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

: 121653-85-8
4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; for 4.5h;
DOI:10.1021/jm00128a032

Reference yield:

: 622-08-2,1201808-31-2
2-Benzyloxyethanol

: 121653-85-8
4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 5.07 g / benzene / 1.5 h / Heating

2: Et₃N / CH₂Cl₂ / 1.25 h / -18 - -15 °C

3: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) SnCl₄ / 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h

4: MeOH, NaOMe / 2.5 h

5: tetrahydrofuran; dioxane / 4.5 h / Heating

6: 89 percent / 1.0 N LiOH / tetrahydrofuran; H₂O / 4.5 h

With methanol; lithium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; sodium methylate; triethylamine; tin(IV) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene;
DOI:10.1021/jm00128a032

Reference yield:

: 121653-72-3
(2-Benzyloxy-ethoxy)-hydroxy-acetic acid methyl ester

: 121653-85-8
4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 1.25 h / -18 - -15 °C

2: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) SnCl₄ / 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h

3: MeOH, NaOMe / 2.5 h

4: tetrahydrofuran; dioxane / 4.5 h / Heating

5: 89 percent / 1.0 N LiOH / tetrahydrofuran; H₂O / 4.5 h

With methanol; lithium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; sodium methylate; triethylamine; tin(IV) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jm00128a032