(1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

Base Information

Chemical Name:(1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
CAS No.:1358579-22-2
Molecular Formula:C₂₂H₂₄ClFO₇
Molecular Weight:454.88
Hs Code.:

Synonyms:(1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

Chemical Property:

Boiling Point:632.3±55.0 °C(Predicted)
Density:1.494±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

There total 15 articles about (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

: 1358580-50-3
[(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]-phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol

: 1358579-22-2
(1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

Guidance literature:: With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; water; at 30 ℃; for 8h; Reagent/catalyst; Catalytic behavior;

Reference yield: 81.0%

: 1358580-51-4
[(1S,2S,3S,4R,5S)-2,3,4-tribenzyloxy-5-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-6,8-dioxabicyclo[3.2.1]octan-1-yl]methanol

: 1358579-22-2
(1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; dichloromethane; for 3h;

Reference yield:

: 1358580-46-7
(2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde

: 1358579-22-2
(1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / 1,4-dioxane / 16 h / 70 °C

2: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h

3: trifluoroacetic acid / dichloromethane / 2 h / -10 °C

4: palladium 10% on activated carbon; hydrogen / dichloromethane; tetrahydrofuran; methanol / 3 h

With methanol; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;